Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최동호 | - |
dc.date.accessioned | 2016-09-28T01:38:24Z | - |
dc.date.available | 2016-09-28T01:38:24Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | Korean Journal of Urology, v. 56, Page. 280-287 | - |
dc.identifier.issn | 2005-6737 | - |
dc.identifier.issn | 2005-6745 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/23477 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4111/kju.2015.56.4.280 | - |
dc.description.abstract | Purpose This study was performed to examine the treatment of erectile dysfunction by use of superparamagnetic iron oxide nanoparticles-labeled human mesenchymal stem cells (SPION-MSCs) transplanted into the cavernous nerve injured cavernosa of rats as monitored by molecular magnetic resonance imaging (MRI). Materials and Methods Eight-week-old male Sprague-Dawley rats were divided into three groups of 10 rats each: group 1, sham operation; group 2, cavernous nerve injury; group 3, SPION-MSC treatment after cavernous nerve injury. Immediately after the cavernous nerve injury in group 3, SPION-MSCs were injected into the cavernous nerve injured cavernosa. Serial T2-weighted MRI was done immediately after injection and at 2 and 4 weeks. Erectile response was assessed by cavernous nerve stimulation at 2 and 4 weeks. Results Prussian blue staining of SPION-MSCs revealed abundant uptake of SPION in the cytoplasm. After injection of 1×106 SPION-MSCs into the cavernosa of rats, T2-weighted MRI showed a clear hypointense signal induced by the injection. The presence of SPION in the corpora cavernosa was confirmed with Prussian blue staining. At 2 and 4 weeks, rats with cavernous nerve injury had significantly lower erectile function than did rats without cavernous nerve injury (p<0.05). The group transplanted with SPION-MSCs showed higher erectile function than did the group without SPION-MSCs (p<0.05). The presence of SPION-MSCs for up to 4 weeks was confirmed by MRI imaging and Prussian blue staining in the corpus cavernosa. Conclusions Transplanted SPION-MSCs existed for up to 4 weeks in the cavernous nerve injured cavernosa of rats. Erectile dysfunction recovered and could be monitored by MRI. | - |
dc.description.sponsorship | This research was supported by a Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0011678) and Soonchunhyang University Research Fund. | - |
dc.publisher | Korean Urological Association | - |
dc.subject | Erectile dysfunction | - |
dc.subject | Magnetic resonance imaging | - |
dc.subject | Mesenchymal stem cell transplantation | - |
dc.subject | Nanoparticles | - |
dc.title | use of nanoparticles to monitor human mesenchymal stem cells transplanted into penile cavernosum of rats with erectile dysfunction | - |
dc.type | Article | - |
dc.relation.volume | 56 | - |
dc.identifier.doi | 10.4111/kju.2015.56.4.280 | - |
dc.relation.page | 280-287 | - |
dc.relation.journal | Korean Journal of Urology | - |
dc.contributor.googleauthor | Kim, Jae Heon | - |
dc.contributor.googleauthor | Lee, Hong Jun | - |
dc.contributor.googleauthor | Doo, Seung Hwan | - |
dc.contributor.googleauthor | Yang, Won Jae | - |
dc.contributor.googleauthor | Choi, Dongho | - |
dc.contributor.googleauthor | Kim, Jung Hoon | - |
dc.contributor.googleauthor | Won, Jong Ho | - |
dc.contributor.googleauthor | Song, Yun Seob | - |
dc.relation.code | 2015031559 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | crane87 | - |
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