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dc.identifier.citationKorean Journal of Urology, v. 56, Page. 280-287-
dc.description.abstractPurpose This study was performed to examine the treatment of erectile dysfunction by use of superparamagnetic iron oxide nanoparticles-labeled human mesenchymal stem cells (SPION-MSCs) transplanted into the cavernous nerve injured cavernosa of rats as monitored by molecular magnetic resonance imaging (MRI). Materials and Methods Eight-week-old male Sprague-Dawley rats were divided into three groups of 10 rats each: group 1, sham operation; group 2, cavernous nerve injury; group 3, SPION-MSC treatment after cavernous nerve injury. Immediately after the cavernous nerve injury in group 3, SPION-MSCs were injected into the cavernous nerve injured cavernosa. Serial T2-weighted MRI was done immediately after injection and at 2 and 4 weeks. Erectile response was assessed by cavernous nerve stimulation at 2 and 4 weeks. Results Prussian blue staining of SPION-MSCs revealed abundant uptake of SPION in the cytoplasm. After injection of 1×106 SPION-MSCs into the cavernosa of rats, T2-weighted MRI showed a clear hypointense signal induced by the injection. The presence of SPION in the corpora cavernosa was confirmed with Prussian blue staining. At 2 and 4 weeks, rats with cavernous nerve injury had significantly lower erectile function than did rats without cavernous nerve injury (p<0.05). The group transplanted with SPION-MSCs showed higher erectile function than did the group without SPION-MSCs (p<0.05). The presence of SPION-MSCs for up to 4 weeks was confirmed by MRI imaging and Prussian blue staining in the corpus cavernosa. Conclusions Transplanted SPION-MSCs existed for up to 4 weeks in the cavernous nerve injured cavernosa of rats. Erectile dysfunction recovered and could be monitored by MRI.-
dc.description.sponsorshipThis research was supported by a Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0011678) and Soonchunhyang University Research Fund.-
dc.publisherKorean Urological Association-
dc.subjectErectile dysfunction-
dc.subjectMagnetic resonance imaging-
dc.subjectMesenchymal stem cell transplantation-
dc.titleuse of nanoparticles to monitor human mesenchymal stem cells transplanted into penile cavernosum of rats with erectile dysfunction-
dc.relation.journalKorean Journal of Urology-
dc.contributor.googleauthorKim, Jae Heon-
dc.contributor.googleauthorLee, Hong Jun-
dc.contributor.googleauthorDoo, Seung Hwan-
dc.contributor.googleauthorYang, Won Jae-
dc.contributor.googleauthorChoi, Dongho-
dc.contributor.googleauthorKim, Jung Hoon-
dc.contributor.googleauthorWon, Jong Ho-
dc.contributor.googleauthorSong, Yun Seob-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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