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dc.contributor.author김민규-
dc.date.accessioned2016-09-27T00:56:38Z-
dc.date.available2016-09-27T00:56:38Z-
dc.date.issued2015-03-
dc.identifier.citationWORLD JOURNAL OF SURGERY, v. 39, NO 3, Page. 732-739en_US
dc.identifier.issn0364-2313-
dc.identifier.issn1432-2323-
dc.identifier.urihttp://search.proquest.com/docview/1652638221?accountid=11283-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/23458-
dc.description.abstractBackground The aim of this study was to investigate the prognostic value of lymphovascular invasion (LVI) in gastric cancer patients without lymph node metastasis. Methods A total of 699 patients with primary tumor pT1-3/pN0-1 gastric adenocarcinoma who underwent curative resection from 2001 to 2010 were categorized into 3 groups: One-hundred and eleven patients with pN0/LVI(+), 475 with pN0/LVI(-), and 103 with pN1. Results The tumors in patients with N0/LVI(+) had more aggressive clinicopathologic features than those in patients with N0/LVI(-). However, there was no significant difference in patient characteristics between patients with pN0/LVI(+) and those with pN1, except for histologic grade. There were no significant differences in the overall survival rate in patients with pN0/LVI(+) compared to those with pN0/LVI(-) or the pN1 stage. However, the recurrence-free survival rate of the pN0/LVI(+) group was lower than that of the pN0/LVI(-) group (p ˂ 0.001), while no significant difference was observed between the pN0/LVI(+) and the N1 groups (p = 0.216). In multi-variate analysis, LVI was identified as a poor prognostic factor related to recurrence-free survival in node-negative gastric cancer patients. pT3 stage and less than D2 lymphadenectomy were poor prognostic factors affecting recurrence-free survival, and less than D2 lymphadenectomy was an independent poor prognostic factor for overall survival in pN0/LVI(+) patients. Conclusions LVI could be an indicator of biological aggressiveness and may be a reliable prognostic factor for node-negative gastric cancer. LVI should be considered in postoperative management of gastric cancer.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectVESSEL INVASIONen_US
dc.subjectMETASTASISen_US
dc.subjectIMPACTen_US
dc.subjectBLOODen_US
dc.titlePrognostic Significance of Lymphovascular Invasion in Node-Negative Gastric Canceren_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume39-
dc.identifier.doi10.1007/s00268-014-2846-y-
dc.relation.page732-739-
dc.relation.journalWORLD JOURNAL OF SURGERY-
dc.contributor.googleauthorLee, Ju-Hee-
dc.contributor.googleauthorKim, Min Gyu-
dc.contributor.googleauthorJung, Min-Sung-
dc.contributor.googleauthorKwon, Sung Joon-
dc.relation.code2015002021-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmd9650-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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