252 0

Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation

Title
Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation
Author
김계성
Keywords
Alginate; Poly-L-lysine; PLL; Nanoparticle; Microfluidic mixing; Polyelectrolyte complexation
Issue Date
2015-03
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 471, Page. 86-92
Abstract
Alginate-based nanoparticles were generated by mixing two types of stock solutions through a microfluidic device. In our microfluidic mixing device, aqueous Ca-alginate pre-gels and cationic poly-L-lysine (PLL) solutions were mixed, and the polyelectrolyte complexation that subsequently occurred between the pre-gel and PLL resulted in precipitates, yielding alginate nanoparticles. Due to the faster microfluidic mixing achieved compared with that obtained with the conventional bulk mixing method, the alginate nanoparticles exhibited enhanced aggregation stability. The control of the size of the nanoparticles through the tuning of the flow rates in the microfluidic device was also achieved. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0927775715001594http://hdl.handle.net/20.500.11754/23365
ISSN
0927-7757; 1873-4359
DOI
10.1016/j.colsurfa.2015.02.029
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE