Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation
- Title
- Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation
- Author
- 김계성
- Keywords
- Alginate; Poly-L-lysine; PLL; Nanoparticle; Microfluidic mixing; Polyelectrolyte complexation
- Issue Date
- 2015-03
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 471, Page. 86-92
- Abstract
- Alginate-based nanoparticles were generated by mixing two types of stock solutions through a microfluidic device. In our microfluidic mixing device, aqueous Ca-alginate pre-gels and cationic poly-L-lysine (PLL) solutions were mixed, and the polyelectrolyte complexation that subsequently occurred between the pre-gel and PLL resulted in precipitates, yielding alginate nanoparticles. Due to the faster microfluidic mixing achieved compared with that obtained with the conventional bulk mixing method, the alginate nanoparticles exhibited enhanced aggregation stability. The control of the size of the nanoparticles through the tuning of the flow rates in the microfluidic device was also achieved. (C) 2015 Elsevier B.V. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0927775715001594http://hdl.handle.net/20.500.11754/23365
- ISSN
- 0927-7757; 1873-4359
- DOI
- 10.1016/j.colsurfa.2015.02.029
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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