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dc.contributor.author김인영-
dc.date.accessioned2016-09-20T05:03:45Z-
dc.date.available2016-09-20T05:03:45Z-
dc.date.issued2015-03-
dc.identifier.citationINTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING, v. 16, NO 3, Page. 573-579en_US
dc.identifier.issn2234-7593-
dc.identifier.issn2005-4602-
dc.identifier.urihttp://link.springer.com/article/10.1007/s12541-015-0077-2-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/23232-
dc.description.abstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used in the treatment of Parkinson’s disease. DBS surgery is usually performed with the patient under local anesthesia (LA). However, a number of patients do not tolerate LA due to anxiety or severe pain. These patients require surgery under sedation or general anesthesia. Unfortunately, anesthetic drugs interfere with the intraoperative microelectrode recordings. A debate regarding the usefulness of sedation or general anesthesia during DBS surgery is still in progress. In this study, we evaluated whether the differences in anesthetic methods affect STN single-unit activity and movement symptoms of Parkinson’s disease. Eight patients underwent surgery to implant bilateral STN DBS electrodes. Our study compares STN single-unit activity under both LA and monitored anesthesia care (MAC) in the same patients as well as movement symptoms of Parkinson’s disease. The primary results revealed no significant difference in the mean firing rate of STN single-unit activity under LA and MAC. However, there were differences in the spike characteristics and firing patterns of STN activity between the two anesthetic methods. These findings contribute valuable insight into the effects of different anesthetic methods on STN single-unit activity for precise electrode localization during DBS surgery.en_US
dc.description.sponsorshipThis study was supported by the Ministry for Health and Welfare (HI09C1354-A092052) and the National Research Foundation of Korea (No. 2013R1A2A2A04014987) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherKOREAN SOC PRECISION ENGen_US
dc.subjectDeep brain stimulationen_US
dc.subjectNeuronal activityen_US
dc.subjectParkinson's diseaseen_US
dc.titleThe Effects of Different Anesthetic Methods on Neuronal Activity and Movement Symptoms of Parkinson's Diseaseen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume16-
dc.identifier.doi10.1007/s12541-015-0077-2-
dc.relation.page573-579-
dc.relation.journalINTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-
dc.contributor.googleauthorPark, Eunkyoung-
dc.contributor.googleauthorHeo, Man Seung-
dc.contributor.googleauthorLim, Yong Hoon-
dc.contributor.googleauthorJang, Dong Pyo-
dc.contributor.googleauthorKim, Hee Chan-
dc.contributor.googleauthorPark, Hee Pyoung-
dc.contributor.googleauthorKim, Dong Gyu-
dc.contributor.googleauthorJeon, Beom Seok-
dc.contributor.googleauthorKim, In Young-
dc.contributor.googleauthorPaek, Sun Ha-
dc.relation.code2015005980-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidiykim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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