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dc.contributor.author윤호주-
dc.date.accessioned2016-09-13T05:44:55Z-
dc.date.available2016-09-13T05:44:55Z-
dc.date.issued2015-03-
dc.identifier.citationSCANDINAVIAN JOURNAL OF IMMUNOLOGY, v. 81, Page. 166-176en_US
dc.identifier.issn1365-3083-
dc.identifier.issn0300-9475-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/sji.12263/full-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/23164-
dc.description.abstractThe CC chemokine eotaxin contributes to epithelium-induced inflammation in airway diseases such as asthma. Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone), a bioactive component of Artemisia asiatica Nakai (Asteraceae), is reported to inhibit the adhesion of eosinophils to bronchial epithelial cells. However, little is known about the molecular mechanism of eupatilin-induced attenuation of bronchial epithelium-induced inflammation. In this study, we investigated the effect of eupatilin on expression of eotaxin-1 (CCL11), a potent chemoattractant for eosinophils. Eupatilin significantly inhibited eotaxin expression in bronchial epithelial cells stimulated with TNF-, while NF-B and IB kinase (IKK) activities declined concurrently. Eupatilin also inhibited mitogen-activated protein kinase (MAPK) activity; however, all of these anti-inflammatory activities were reversed by MAPK overexpression. In contrast, eupatilin did not affect the signal transducer and activator of transcription 6 (STAT6) signalling in bronchial epithelial cells stimulated with IL-4. Furthermore, eupatilin significantly attenuated TNF--induced eosinophil migration. These results suggest that the eupatilin inhibits the signalling of MAPK, IKK, NF-B and eotaxin-1 in bronchial epithelial cells, leading to inhibition of eosinophil migration.en_US
dc.description.sponsorshipThis research was supported by the Research Fund of Hanyang University (HY-2014).en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.titleThe Flavone Eupatilin Inhibits Eotaxin Expression in an NF-kappa B-Dependent and STAT6-Independent Manneren_US
dc.typeArticleen_US
dc.relation.volume81-
dc.identifier.doi10.1111/sji.12263-
dc.relation.page166-176-
dc.relation.journalSCANDINAVIAN JOURNAL OF IMMUNOLOGY-
dc.contributor.googleauthorJeon, J. I.-
dc.contributor.googleauthorKo, S. H.-
dc.contributor.googleauthorKim, Y.-J.-
dc.contributor.googleauthorChoi, S.M.-
dc.contributor.googleauthorKang, K. K.-
dc.contributor.googleauthorKim, H.-
dc.contributor.googleauthorYoon, H. J.-
dc.contributor.googleauthorKim, J. M.-
dc.relation.code2015001735-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhjyoon-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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