Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정목 | - |
dc.date.accessioned | 2016-08-30T04:22:22Z | - |
dc.date.available | 2016-08-30T04:22:22Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.citation | SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v. 81, NO 3, Page. 166-176 | en_US |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.issn | 1365-3083 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/sji.12263/full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22851 | - |
dc.description.abstract | The CC chemokine eotaxin contributes to epithelium-induced inflammation in airway diseases such as asthma. Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone), a bioactive component of Artemisia asiatica Nakai (Asteraceae), is reported to inhibit the adhesion of eosinophils to bronchial epithelial cells. However, little is known about the molecular mechanism of eupatilin-induced attenuation of bronchial epithelium-induced inflammation. In this study, we investigated the effect of eupatilin on expression of eotaxin-1 (CCL11), a potent chemoattractant for eosinophils. Eupatilin significantly inhibited eotaxin expression in bronchial epithelial cells stimulated with TNF-, while NF-B and IB kinase (IKK) activities declined concurrently. Eupatilin also inhibited mitogen-activated protein kinase (MAPK) activity; however, all of these anti-inflammatory activities were reversed by MAPK overexpression. In contrast, eupatilin did not affect the signal transducer and activator of transcription 6 (STAT6) signalling in bronchial epithelial cells stimulated with IL-4. Furthermore, eupatilin significantly attenuated TNF--induced eosinophil migration. These results suggest that the eupatilin inhibits the signalling of MAPK, IKK, NF-B and eotaxin-1 in bronchial epithelial cells, leading to inhibition of eosinophil migration. | en_US |
dc.description.sponsorship | Hanyang University | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | BACTEROIDES-FRAGILIS ENTEROTOXIN | en_US |
dc.subject | INTESTINAL EPITHELIAL-CELLS | en_US |
dc.subject | INTERCELLULAR-ADHESION MOLECULE-1 | en_US |
dc.subject | PYLORI VACUOLATING CYTOTOXIN | en_US |
dc.subject | ALLERGIC AIRWAY INFLAMMATION | en_US |
dc.subject | CLOSTRIDIUM-DIFFICILE TOXIN | en_US |
dc.subject | SEVERE ASTHMA | en_US |
dc.subject | TNF-ALPHA | en_US |
dc.subject | PATHWAY | en_US |
dc.subject | EOSINOPHILS | en_US |
dc.title | The Flavone Eupatilin Inhibits Eotaxin Expression in an NF-kappa B-Dependent and STAT6-Independent Manner | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 81 | - |
dc.identifier.doi | 10.1111/sji.12263 | - |
dc.relation.page | 166-176 | - |
dc.relation.journal | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | - |
dc.contributor.googleauthor | Jeon, J. I. | - |
dc.contributor.googleauthor | Ko, S. H. | - |
dc.contributor.googleauthor | Kim, Y. -J. | - |
dc.contributor.googleauthor | Choi, S. M. | - |
dc.contributor.googleauthor | Kang, K. K. | - |
dc.contributor.googleauthor | Kim, H. | - |
dc.contributor.googleauthor | Yoon, H. J. | - |
dc.contributor.googleauthor | Kim, J. M. | - |
dc.relation.code | 2015001735 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jungmogg | - |
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