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Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer's Disease

Title
Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer's Disease
Author
김희진
Keywords
rivastigmine transdermal patch; Alzheimer's disease; tolerability
Issue Date
2015-03
Publisher
대한치매학회
Citation
Dementia and Neurocognitive Disorders(대한치매학회지), Page. 31-38
Abstract
Background and Purpose The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patients show more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patients with Alzheimer's disease (AD) and the specific factors affecting adverse events of the skin. Methods A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009 to September 2010 (NCT01312363). Results A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinued treatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergic history and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment. Conclusion These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding and improving skin tolerability to the rivastigmine patch.
URI
http://synapse.koreamed.org/search.php?where=aview&id=10.12779/dnd.2015.14.1.31&code=0196DND&vmode=FULLhttp://hdl.handle.net/20.500.11754/22628
ISSN
1738-1495; 2384-0757
DOI
10.12779/dnd.2015.14.1.31
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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