Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heese, Klaus | - |
dc.date.accessioned | 2016-07-29T05:18:51Z | - |
dc.date.available | 2016-07-29T05:18:51Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | TUMOR BIOLOGY, NO 36(1), Page. 239-249 | en_US |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.issn | 1423-0380 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007/s13277-014-2620-7 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22321 | - |
dc.description.abstract | FAM72A (p17) is a novel neuronal protein that has been linked to tumorigenic effects in non-neuronal tissue. Using state of the art in silico physicochemical analyses (e.g., I-TASSER, RaptorX, and Modeller), we determined the three-dimensional (3D) protein structure of FAM72A and further identified potential ligand-protein interactions. Our data indicate a Zn2+/Fe3+-containing 3D protein structure, based on a 3GA3_A model template, which potentially interacts with the organic molecule RSM ((2s)-2-(acetylamino)-N-methyl-4-[(R)-methylsulfinyl] butanamide). The discovery of RSM may serve as potential lead for further anti-FAM72A drug screening tests in the pharmaceutical industry because interference with FAM72A's activities via RSM-related molecules might be a novel option to influence the tumor suppressor protein p53 signaling pathways for the treatment of various types of cancers. | en_US |
dc.description.sponsorship | Hanyang University | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Ugene | en_US |
dc.subject | FAM72A | en_US |
dc.subject | In silico | en_US |
dc.subject | 3D structure | en_US |
dc.subject | Cancer | en_US |
dc.subject | RSM | en_US |
dc.title | Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17) | en_US |
dc.type | Article | en_US |
dc.relation.no | 36(1) | - |
dc.identifier.doi | 10.1007/s13277-014-2620-7 | - |
dc.relation.page | 239-249 | - |
dc.relation.journal | TUMOR BIOLOGY | - |
dc.contributor.googleauthor | Pramanik, Subrata | - |
dc.contributor.googleauthor | Kutzner, Arne | - |
dc.contributor.googleauthor | Heese, Klaus | - |
dc.relation.code | 2015001496 | - |
dc.sector.campus | S | - |
dc.sector.daehak | Graduate School of Biomedical Science & Engineering[S] | - |
dc.identifier.pid | klaus | - |
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