Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송이선 | - |
dc.date.accessioned | 2016-07-26T07:38:48Z | - |
dc.date.available | 2016-07-26T07:38:48Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | ANNALS OF HEPATOLOGY, v. 14, NO 2, Page. 243-250 | en_US |
dc.identifier.issn | 1665-2681 | - |
dc.identifier.uri | http://new.medigraphic.com/cgi-bin/resumen.cgi?IDARTICULO=57808 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22236 | - |
dc.description.abstract | Background and aims. Previously, we reported that granulocyte-colony stimulating factor (G-CSF) improves hepatic steatosis in experimental animals. It may also have preventive effects on the development of hepatic steatosis. Therefore, we investigated the preventive effects of G-CSF by using a high-fat diet (HFD) rat model. Materials and methods. Twelve rats were fed HFD and 6 rats were fed control diet from 10 weeks of age. Once little steatosis was confirmed in the liver (after 10 weeks of feeding the HFD; at 20 weeks of age), HFD rats were randomly divided into two groups and treated with either G-CSF (100 mu g kg(-1) day(-1) for 5 consecutive days every other week; HFD/G-CSF rats) or saline (HFD/saline rats) for 10 weeks at 20 weeks of age. All rats were sacrificed at 30 weeks of age. Histology was examined by hematoxylin and eosin (H-E) and Oil Red 0 staining, and the expression levels of genes of associated with lipogenesis and beta-oxidation enzymes were determined by qRT-PCR. Results. Histological examinations revealed that HFD/G-CSF rats had significantly lower lipid accumulation in their hepatocytes than did HFD/saline rats (p < 0.05). HFD/G-CSF rats also showed lower expression levels of genes associated with lipogenesis and higher expression levels of genes associated with beta-oxidation than HFD/saline rats (p < 0.05). Conclusion. In conclusion, we found that G-CSF prevented development of hepatic steatosis in an HFD rat model. The preventive effect may be associated with the regulation of gene expression involved in hepatic lipogenesis and beta-oxidation. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MEXICAN ASSOC HEPATOLOGY | en_US |
dc.subject | High-fat diet | en_US |
dc.subject | Lipogenesis | en_US |
dc.subject | beta-oxidation | en_US |
dc.title | Granulocyte-colony stimulating factor prevents the development of hepatic steatosis in rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 14 | - |
dc.relation.page | 243-250 | - |
dc.relation.journal | ANNALS OF HEPATOLOGY | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | Joo, Hyun-Woo | - |
dc.contributor.googleauthor | Park, In-Hwa | - |
dc.contributor.googleauthor | Shen, Guang-Yin | - |
dc.contributor.googleauthor | Lee, Yonggu | - |
dc.contributor.googleauthor | Shin, Jeong Hun | - |
dc.contributor.googleauthor | Kim, Hyuck | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.relation.code | 2015012112 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | INSTITUTE OF BIOMEDICAL SCIENCE | - |
dc.identifier.pid | yisun486 | - |
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