Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김교상 | - |
dc.date.accessioned | 2016-07-21T01:07:23Z | - |
dc.date.available | 2016-07-21T01:07:23Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | BMC ANESTHESIOLOGY, v. 15, NO 7, Page. 1-6 | en_US |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | http://bmcanesthesiol.biomedcentral.com/articles/10.1186/1471-2253-15-7 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/22139 | - |
dc.description.abstract | Background: Mild hypothermia may be frequently induced due to cool environments in the operating room. The study analyzed patient recovery time and response to sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) during mild hypothermia. Methods: Sixty patients were randomly (1: 1) allocated to the mild hypothermia and normothermia groups, defined as having core temperatures between 34.5 -35 degrees C and 36.5-37 degrees C, respectively. Patients received 0.6 mg/kg of rocuronium, followed by 7-10 mu g/kg/min to maintain a deep NMB [post-tetanic count (PTC) 1-2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. The primary end-point was the time until the train-of-four (TOF) ratio was 0.9. Results: The appropriate neuromuscular function (TOF ratio >= 0.9) was restored after sugammadex was administered, even after hypothermia. The length of recovery in the hypothermia patients [mean (SD), 171.1 (62.1) seconds (s)] was significantly slower compared with the normothermia patients [124.9 (59.2) s] (p = 0.005). There were no adverse effects from sugammadex. Conclusions: Sugammadex safely and securely reversed deep rocuronium-induced NMB during mild hypothermia. An additional 46 s was required for recovery from a deep NMB in hypothermia patients. Based on the results, we think this prolonged recovery time is clinically acceptable. | en_US |
dc.description.sponsorship | Korea Merck Sharp & Dohme Corp., a subsidiary of Merck Sharp Dohme Corp. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BIOMED CENTRAL LTD | en_US |
dc.subject | Hypothermia | en_US |
dc.subject | Neuromuscular blockade Rocuronium | en_US |
dc.subject | Sugammadex | en_US |
dc.title | The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 15 | - |
dc.identifier.doi | 10.1186/1471-2253-15-7 | - |
dc.relation.page | 1-6 | - |
dc.relation.journal | BMC ANESTHESIOLOGY | - |
dc.contributor.googleauthor | Lee, Hee Jong | - |
dc.contributor.googleauthor | Kim, Kyo Sang | - |
dc.contributor.googleauthor | Jeong, Ji Seon | - |
dc.contributor.googleauthor | Kim, Kyu Nam | - |
dc.contributor.googleauthor | Lee, Byeong Chan | - |
dc.relation.code | 2015006131 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimks | - |
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