Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 백두진 | - |
dc.date.accessioned | 2016-06-21T05:07:12Z | - |
dc.date.available | 2016-06-21T05:07:12Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF IMMUNOLOGY, v. 45, Page. 167-179 | en_US |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/21821 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/eji.201444532/abstract?systemMessage=Pay+Per+View+on+Wiley+Online+Library+will+be+unavailable+on+Saturday+15th+April+from+12%3A00-09%3A00+EDT+for+essential+maintenance.++Apologies+for+the+inconvenience. | - |
dc.description.abstract | Foxp3 + Treg cells are crucial for maintaining T-cell homeostasis, but their role in B-cell homeostasis remains unclear. Here, we found that Foxp3 mutant scurfy mice had fewer B-lineage cells and progenitors, including common lymphoid progenitors and lymphoid- primed multipotent progenitors, but higher myeloid-lineage cell numbers in BM com- pared with WT littermates. Homeostasis within the HSC compartment was also com- promised with apparent expansion of long- and short-term HSCs. This abnormality was due to the lack of Treg cells, but not to the Treg-cell extrinsic functions of Foxp3 or cell- autonomous defects. Among cytokines enriched in the BM of scurfy mice, IFN-γ affected only B lymphopoiesis, but GM-CSF, TNF, and IL-6 collectively promoted granulopoiesis at the expense of B lymphopoiesis. Neutralization of these three cytokines reversed the hematopoietic defects on early B-cell progenitors in scurfy mice. Treg cells ensured B lymphopoiesis by reducing the production of these cytokines by effector T cells, but not by directly affecting B lymphopoiesis. These results suggest that Treg cells occupy an important niche in the BM to protect B-lineage progenitor cells from excessive exposure to a lymphopoiesis-regulating milieu. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | B lymphopoiesis | en_US |
dc.subject | Foxp3 | en_US |
dc.subject | Granulopoietins | en_US |
dc.subject | Hematopoiesis | en_US |
dc.subject | Regulatory T cells | en_US |
dc.title | Foxp3+ regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow | en_US |
dc.type | Article | en_US |
dc.relation.volume | 45 | - |
dc.identifier.doi | 10.1002/eji.201444532 | - |
dc.relation.page | 167-179 | - |
dc.relation.journal | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.contributor.googleauthor | Kim, Sunghoon | - |
dc.contributor.googleauthor | Park, Kyungsoo | - |
dc.contributor.googleauthor | Choi, Jinwook | - |
dc.contributor.googleauthor | Jang, Eunkyeong | - |
dc.contributor.googleauthor | Paik, Doo‐Jin | - |
dc.contributor.googleauthor | Seong, Rho H. | - |
dc.contributor.googleauthor | Youn, Jeehee | - |
dc.relation.code | 2015003615 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | paikdj | - |
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