Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2016-06-15T07:11:25Z | - |
dc.date.available | 2016-06-15T07:11:25Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, NO 1, Page. 54-59 | en_US |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/21684 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2015.30.1.54 | - |
dc.description.abstract | The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale. Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020 and A102065). | - |
dc.language.iso | en | en_US |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | en_US |
dc.subject | Pulmonary Disease | en_US |
dc.subject | Chronic Obstructive | en_US |
dc.subject | Forced Expiratory Volume | en_US |
dc.subject | Disease Progression | en_US |
dc.title | Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 30 | - |
dc.identifier.doi | 10.3346/jkms.2015.30.1.54 | - |
dc.relation.page | 54-59 | - |
dc.relation.journal | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.contributor.googleauthor | Lee, Jung Su | - |
dc.contributor.googleauthor | Rhee, Chin Kook | - |
dc.contributor.googleauthor | Yoo, Kwang Ha | - |
dc.contributor.googleauthor | Lee, Ji-Hyun | - |
dc.contributor.googleauthor | Yoon, Ho Il | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.relation.code | 2015003059 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | drterry | - |
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