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dc.contributor.author이종민-
dc.date.accessioned2016-06-09T08:27:47Z-
dc.date.available2016-06-09T08:27:47Z-
dc.date.issued2015-01-
dc.identifier.citationJOURNAL OF ALZHEIMERS DISEASE, v. 45, NO 4, Page. 1089-1096en_US
dc.identifier.issn1387-2877-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/21644-
dc.identifier.urihttp://content.iospress.com/articles/journal-of-alzheimers-disease/jad143063-
dc.description.abstractBackground: Emerging evidence suggests that low serum 25-hydroxyvitamin D (25OHD) may induce cognitive decline and dementia, however, the pathophysiological mechanisms are poorly understood. Objective: We sought to determine the relationship between vitamin D deficiency and neuronal integrity in cognitively impaired patients. Methods: One hundred nine patients with memory impairment were divided into quartiles according to serum concentrations of 25OHD concentration, from lowest (L-25OHD) to highest (H-25OHD). The diffusion tensor images from the L-25OHD group and the H-25OHD group were assessed. A mask of regional white matter hyperintensities was obtained in the T1-weighted image space. Data were analyzed using tract-based spatial statistics with a nonlinear registration algorithm. Results: Patients in the L-25OHD group had lower fractional anisotropy values compared with patients in the H-25OHD group in the frontal parts of the inferior and superior longitudinal fasciculi, cingulum bundle, corpus callosum (genu), anterior limb of the internal capsule, and anterior corona radiata (familywise error corrected, p ˂ 0.05). Conclusions: Vitamin D deficiency is associated with disruption of neuronal integrity, primarily in frontal regions. Vitamin D deficiency may lead to the loss of neuroprotective properties in cerebral ischemia and vascular lesions, contributing to memory impairment.en_US
dc.description.sponsorshipThe authors thank Hui Jin Ryu, MA, Min Young Kim, MA, Chung-Hwan Kang, RT, Yeo-Min, Yun,MD, PhD, and the Clinical Research Center for Konkuk University Medical Center Memory Clinic for their support and guidance in the neuropsychological evaluation of patients, serum and imaging data acquisition, and management of this study. Most importantly, the authors thank all those who participated in the study for their dedication to helping research in dementia. Authors’ disclosures available online (http://jalz.com/manuscript-disclosures/14-3063r1).-
dc.language.isoenen_US
dc.publisherIOS PRESSen_US
dc.subjectnutritionalen_US
dc.subjectvitamin Den_US
dc.subjectimagingen_US
dc.subjectCognitive declineen_US
dc.titleVitamin D Deficiency Disrupts Neuronal Integrity in Cognitively Impaired Patientsen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume45-
dc.identifier.doi10.3233/JAD-143063-
dc.relation.page1089-1096-
dc.relation.journalJOURNAL OF ALZHEIMERS DISEASE-
dc.contributor.googleauthorMoon, Yeonsil-
dc.contributor.googleauthorMoon, Won-Jin-
dc.contributor.googleauthorKwon, Hunki-
dc.contributor.googleauthorLee, Jong-Min-
dc.contributor.googleauthorHan, Seol-Heui-
dc.relation.code2015010893-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOENGINEERING-
dc.identifier.pidljm-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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