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dc.contributor.author지용배-
dc.date.accessioned2016-06-09T08:24:57Z-
dc.date.available2016-06-09T08:24:57Z-
dc.date.issued2015-01-
dc.identifier.citationENVIRONMENTAL AND MOLECULAR MUTAGENESIS, v. 56, NO 1, Page. 70-76en_US
dc.identifier.issn0893-6692-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/21642-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/em.21898/full-
dc.description.abstractGenetic factors associated with susceptibility to papillary thyroid carcinoma (PTC) are not well known. We evaluated the association between single nucleotide polymorphisms (SNPs) of ataxia telangiectasia mutated (ATM) and the risk of PTC. A total of 437 histologically confirmed PTC cases and 184 cancer-free controls without thyroid nodules were recruited. Genotypes with respect to five ATM SNPs (rs189037, rs664677, rs373759, rs664143, and rs4585) were determined by the TaqMan assay, and odds ratios and 95% confidence intervals were obtained by logistic regression analysis. Linkage disequilibria and haplotypes were examined from the genotype data. When evaluated separately the genotype distributions of the five ATM SNPs were similar in the PTC cases and controls. Three ATM SNPs (rs373759, rs664143, and rs4585) were found to be in strong linkage disequilibrium (D=1.00, P˂0.001). When the three haplotypes (C-A-G), (T-G-T), and (C-G-T) of these three ATM SNP sites were analyzed, ATM haplotype (C-G-T) +/- was associated with a lower risk of PTC than ATM haplotype (C-G-T) -/- (P=0.03) after adjusting for age and gender. Our results suggest that genetic polymorphisms of ATM may play an important role in the development of thyroid cancer in the Korean population. Environ. Mol. Mutagen. 56:70-76, 2015. (c) 2014 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipDr. Chang Myeon Song and Prof. Kyung Tae designed the study and applied for Research Ethics Board approval. Dr. Chang Myeon Song, Prof. Yong Bae Ji, and Prof. Kyung Tae recruited the patients and collected the data. Dr. Chang Myeon Song and Dr. Byung Lae Park analyzed the data and prepared draft figures and tables. Dr. Chang Myeon Song prepared the draft manuscript with important intellectual input from Prof. Tack-Kyun Kwon and Prof. Kyung Tae. All authors approved the final manuscript. Dr. Chang Myeon Song and Prof. Kyung Tae had access to all the study data.-
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectataxia tela ngiectasia mutateden_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectpapillary t hyroid carcinomaen_US
dc.subjectgenetic polymorphismen_US
dc.titleSingle Nucleotide Polymorphisms of Ataxia Telangiectasia Mutated and the Risk of Papillary Thyroid Carcinomaen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume56-
dc.identifier.doi10.1002/em.21898-
dc.relation.page70-76-
dc.relation.journalENVIRONMENTAL AND MOLECULAR MUTAGENESIS-
dc.contributor.googleauthorSong, Chang Myeon-
dc.contributor.googleauthorKwon, Tack‐Kyun-
dc.contributor.googleauthorPark, Byung Lae-
dc.contributor.googleauthorJi, Yong Bae-
dc.contributor.googleauthorTae, Kyung-
dc.relation.code2015002030-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjyb20000-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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