Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영복 | - |
dc.date.accessioned | 2024-09-03T02:15:05Z | - |
dc.date.available | 2024-09-03T02:15:05Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | JOURNAL OF MATERIALS CHEMISTRY B, v. 10, no 10, page. 1561-1570 | en_US |
dc.identifier.issn | 2050-7518 | en_US |
dc.identifier.issn | 2050-750X | en_US |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2022/TB/D1TB02509K | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/192074 | - |
dc.description.abstract | Tannic acid (TA) not only prevents drug carriers from sticking to the glycocalyx layer of vascular endothelial cells but also has anti-cancer properties, thereby improving drug delivery efficiency in cancer treatment. This study proposes a TANNylated nanovesicle-based cancer treatment approach by utilizing the aforementioned advantages of TA. We fabricated cancer cell-targeting BC71 peptide-conjugated TANNylated nanovesicles (TANV(BC71)) by covalently bonding the TA derivative and BC71 (cyclo[beta A-kRK(3-maleimidopropionyl)-d-(d-2-naphthyl)]) with thiol-modified phospholipids through the thiol-maleimide reaction. We demonstrated that TANV(BC71) was absorbed faster in high amounts by cancer cells than nanovesicles owing to its high affinity for the epidermal growth factor receptor and extracellular matrix components that are driven by van der Waals attraction as well as hydrogen bonding and hydrophobic interactions in a complex manner. These complex attractions of TANV(BC71) for cancer cells led to the effective induction of cancer cell apoptosis. The findings obtained in this study highlight that the TANV(BC71) system has the potential for intelligent high-efficacy cancer cell drug delivery. | en_US |
dc.description.sponsorship | This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), INNOPOLIS Foundation of Korea (No. 2021-DD-UP-0369) and funded by the Ministry of Health & Welfare, Republic of Korea (No. HP20C0018). | en_US |
dc.language | en_US | en_US |
dc.publisher | ROYAL SOC CHEMISTRY | en_US |
dc.relation.ispartofseries | v. 10, no 10;1561-1570 | - |
dc.title | Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.1039/d1tb02509k | en_US |
dc.relation.page | 1561-1570 | - |
dc.relation.journal | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.contributor.googleauthor | Seo, Jihye | - |
dc.contributor.googleauthor | Kim, Seulgi | - |
dc.contributor.googleauthor | Lee, Yousong | - |
dc.contributor.googleauthor | Kim, Jiwon | - |
dc.contributor.googleauthor | Lee, Youngbok | - |
dc.contributor.googleauthor | Shin, Mikyung | - |
dc.contributor.googleauthor | Kim, Jin Woong | - |
dc.relation.code | 2022036372 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | yblee | - |
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