Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김은혜 | - |
dc.date.accessioned | 2024-08-12T05:41:52Z | - |
dc.date.available | 2024-08-12T05:41:52Z | - |
dc.date.issued | 2022-09-14 | - |
dc.identifier.citation | PARTICLE AND FIBRE TOXICOLOGY, v. 19, no 1, page. 1-15 | en_US |
dc.identifier.issn | 1743-8977 | en_US |
dc.identifier.uri | https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-022-00500-y | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/191547 | - |
dc.description.abstract | Background Microplastics (MPs) and nanoplastics (NPs) formed from decomposed plastic are increasing environmental threats. Although MPs and NPs exposed through various routes enter the systemic circulation, the potential toxicity of those is largely unknown. We investigated whether polystyrene NPs (PS-NPs) promote the coagulation activity of red blood cells (RBCs). Results We tested several types of PS-NPs using human RBCs and found that amine-modified 100 nm PS-NPs were the most potent. We measured the uptake of PS-NPs using flow cytometry and confocal microscopy. Electron microscopy revealed morphological changes of RBCs by PS-NPs. PS-NPs induced the externalization of phosphatidylserine, generation of microvesicles in RBCs, and perturbations in the intracellular microenvironment. PS-NPs increased the activity of scramblases responsible for phospholipid translocation in RBCs. PS-NPs modulated the functional interaction to adjacent tissues and coagulation cascade, enhancing RBC adhesion and thrombin generation. Our observations in human RBCs were consistent with those in isolated rat RBCs, showing no inter-species differences. In rat venous thrombosis models, the intravenous administration of PS-NPs enhanced thrombus formation. Conclusion Amine-modified PS-NPs induce the prothrombotic activation of RBCs causing thrombus formation. We believe that our study will contribute to understanding the potential toxicity of amine-modified polystyrene particles in blood cells and cardiovascular systems. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea, funded by the Ministry of Science, ICT, and Future Planning (2021R1I1A1A01049980 to H.Y.C. and 2017R1C1B3002626 and 2022R1A2C4001434 to O.-N. B.). | en_US |
dc.language | en_US | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartofseries | v. 19, no 1;1-15 | - |
dc.subject | Microplastics | en_US |
dc.subject | Nanoplastics | en_US |
dc.subject | Cardiovascular systems | en_US |
dc.subject | Red blood cells | en_US |
dc.subject | Procoagulation activity | en_US |
dc.title | Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1186/s12989-022-00500-y | en_US |
dc.relation.page | 60-60 | - |
dc.relation.journal | PARTICLE AND FIBRE TOXICOLOGY | - |
dc.contributor.googleauthor | Kim, Eun-Hye | - |
dc.contributor.googleauthor | Choi, Sungbin | - |
dc.contributor.googleauthor | Kim, Donghyun | - |
dc.contributor.googleauthor | Park, Han Jin | - |
dc.contributor.googleauthor | Bian, Yiying | - |
dc.contributor.googleauthor | Choi, Sang Ho | - |
dc.contributor.googleauthor | Chung, Han Young | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.relation.code | 2022043313 | - |
dc.sector.campus | E | - |
dc.sector.daehak | RESEARCH INSTITUTE[E] | - |
dc.sector.department | INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY | - |
dc.identifier.pid | dldh615 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.