Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재용 | - |
dc.date.accessioned | 2024-06-26T04:57:19Z | - |
dc.date.available | 2024-06-26T04:57:19Z | - |
dc.date.issued | 2022-12-29 | - |
dc.identifier.citation | PLANTS-BASEL, v. 12, no 163, page. 1-8 | en_US |
dc.identifier.issn | 2223-7747 | en_US |
dc.identifier.uri | https://www.mdpi.com/2223-7747/12/1/163 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/190990 | - |
dc.description.abstract | The unsaturated aldehyde trans-2-nonenal is known to be generated by lipid peroxidation at the surface of the skin in an aging-related manner and has harmful effects on keratinocytes in the skin. In this study, the protective effect of a Lycii Radicis Cortex (LRC) extract against trans-2-nonenal-induced cell damage on human keratinocyte cell lines (HaCaT) was investigated. Notably, treatment with the LRC extract resulted in an increase in cell survival, while trans-2-nonenal decreased the viability of HaCaT cells. For identification of interaction between the LRC extract and trans-2-nonenal, this mixture was incubated in simulated physiological conditions, showing a strong decrease in the amount of trans-2-nonenal by the LRC extract. Subsequent LC-ESI-MS analysis revealed that kukoamine B (KB) formed Schiff base-derived pyridinium adducts with trans-2-nonenal. Thus, these results suggest that KB could be a potential agent that may protect HaCaT cells by forming new products with trans-2-nonenal. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2020R1A2C1009455 and NRF-2020R1A6A1A03042854). | en_US |
dc.language | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartofseries | v. 12, no 163;1-8 | - |
dc.subject | kukoamine B | en_US |
dc.subject | Lycii Radicis Cortex | en_US |
dc.subject | trans-2-nonenal | en_US |
dc.subject | keratinocytes | en_US |
dc.subject | pyridinium derivatives | en_US |
dc.title | Kukoamine B from Lycii Radicis Cortex Protects Human Keratinocyte HaCaT Cells through Covalent Modification by Trans-2-Nonenal | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/plants12010163 | en_US |
dc.relation.page | 163-163 | - |
dc.relation.journal | PLANTS-BASEL | - |
dc.contributor.googleauthor | Kim, Hye Mi | - |
dc.contributor.googleauthor | Kim, Jae Yong | - |
dc.contributor.googleauthor | Kim, Ji Hoon | - |
dc.contributor.googleauthor | Kim, Chul Young | - |
dc.relation.code | 2022037778 | - |
dc.sector.campus | E | - |
dc.sector.daehak | RESEARCH INSTITUTE[E] | - |
dc.sector.department | INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY | - |
dc.identifier.pid | kjaey0331 | - |
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