Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승환 | - |
dc.date.accessioned | 2024-04-22T00:27:54Z | - |
dc.date.available | 2024-04-22T00:27:54Z | - |
dc.date.issued | 2023-03-01 | - |
dc.identifier.citation | ADVANCED MATERIALS, Volume 35, Issue 19, Article No. 2206198 | en_US |
dc.identifier.issn | 0935-9648 | en_US |
dc.identifier.issn | 1521-4095 | en_US |
dc.identifier.uri | https://information.hanyang.ac.kr/#/eds/detail?an=000966785500001&dbId=edswsc | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/189896 | - |
dc.description.abstract | The sense of spiciness is related to the stimulation of vanilloid compounds contained in the foods. Although, the spiciness is commonly considered as the part of taste, it is more classified to the sense of pain stimulated on a tongue, namely, pungency, which is described as a tingling or burning on the tongue. Herein, first, a reusable electronic tongue based on a transient receptor potential vanilloid 1 (TRPV1) nanodisc conjugated graphene field-effect transistor is fabricated and spiciness-related pain evaluation with reusable electrode is demonstrated. The pungent compound reactive receptor TRPV1 is synthesized in the form of nanodiscs to maintain stability and reusability. The newly developed platform shows highly selective and sensitive performance toward each spiciness related vanilloid compound repeatably: 1 aM capsaicin, 10 aM dihydrocapsaicin, 1 fM piperine, 10 nM allicin, and 1 pM AITC. The binding mechanism is also examined by simulation. Furthermore, the elimination of the burning sensation on the tongue after eating spicy foods is not investigated. Based on the synthesis of micelles composed of casein protein (which is contained in skim milk) that remove pungent compounds bound to TRPV1 nanodisc, the deactivation of TRPV1 is investigated, and the electrode is reusable that mimics electronic tongue. | en_US |
dc.description.sponsorship | S.E.S., S.G.L., and K.H.K. contributed equally to the manuscript preparation and data collection. This work was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry(IPET) and Korea Smart Farm R&D Foundation(KosFarm) through Smart Farm Innovation Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA) and Ministry of Science and ICT(MSIT), Rural Development Administration(RDA) (421020-03); the National Research Council of Science & Technology (NST) grant by the Korea government (MSIT) (CAP22011-000); Korea Ministry of Environment (MOE) through Technology Development Project for Safety Management of Household Chemical Products Program (or Project), funded by Korea Ministry of Environment (MOE)(2022002980005, 1485018893, 2022002980009, 1485018881); Nanomedical Devices Development Project of NNFC in 2023 and the Korea Research Institute of Bioscience and Biotechnology(KRIBB) Research Initiative Program. | en_US |
dc.language | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.relation.ispartofseries | Volume 35, Issue 19, Article No. 2206198;1-12 | - |
dc.subject | capsaicin | en_US |
dc.subject | graphene transistor | en_US |
dc.subject | pain evaluation | en_US |
dc.subject | reusable electrode | en_US |
dc.subject | transient receptor potential vanilloid 1 | en_US |
dc.title | Reusable Electronic Tongue Based on Transient Receptor Potential Vanilloid 1 Nanodisc-Conjugated Graphene Field-Effect Transistor for a Spiciness-Related Pain Evaluation | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/adma.202206198 | en_US |
dc.relation.page | 2206198-2206198 | - |
dc.relation.journal | ADVANCED MATERIALS | - |
dc.contributor.googleauthor | Seo, Sung Eun | - |
dc.contributor.googleauthor | Lim, Seong Gi | - |
dc.contributor.googleauthor | Kim, Kyung Ho | - |
dc.contributor.googleauthor | Kim, Jinyeong | - |
dc.contributor.googleauthor | Shin, Chan Jae | - |
dc.contributor.googleauthor | Kim, Soomin | - |
dc.contributor.googleauthor | Kim, Lina | - |
dc.contributor.googleauthor | Lee, Seung Hwan | - |
dc.contributor.googleauthor | Jang, Song Yee | - |
dc.contributor.googleauthor | Oh, Hyun Woo | - |
dc.relation.code | 2023037949 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF BIONANO ENGINEERING | - |
dc.identifier.pid | vincero78 | - |
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