Multifunctional composite hydrogels incorporating mineral-coated nanofibers with magnetic nanoparticles for photothermal therapy and bone tissue regeneration
- Title
- Multifunctional composite hydrogels incorporating mineral-coated nanofibers with magnetic nanoparticles for photothermal therapy and bone tissue regeneration
- Author
- 황태연
- Alternative Author(s)
- Taeyeon Hwang
- Advisor(s)
- Heungsoo SHIN
- Issue Date
- 2024. 2
- Publisher
- 한양대학교 대학원
- Degree
- Master
- Abstract
- Osteosarcoma is one of the major bone diseases. The treatment of osteosarcoma typically requires the surgical removal and regeneration of tumor-induced critical bone defects simultaneously. To overcome the problem, multifunctional biomaterials with both tumor therapy and bone regeneration functions are required. In this study, we prepared a composite hydrogel that incorporates mineral-coated magnetic nanofibers (G-mMFs) using electrospinning and surface modification techniques. G-mMFs combine a high photothermal effect with improved bone regeneration abilities. Specifically, our G-mMFs exhibited remarkable photothermal effects even when exposed to an ultralow power density of 1.5 W/cm² through the irradiation of 808 nm near-infrared (NIR) laser, unlike pure G-mMFs that did not show any such effect. The photothermal effect of G-mMFs, can be modulated based on the concentration of fibers. In the 8 mg/mL group, the temperature increased to 44°C, resulting in over 80% cell apoptosis of human osteosarcoma (MG63) in vitro. Additionally, G-mMFs enhance the upregulation of osteogenic differentiation in human adipose-derived stem cells (hADSCs) and demonstrate significant bone formation in the calvarial defect model in mice. Our results demonstrate the multifunctional properties of the prepared G-mMFs in photothermal effect and bone tissue regeneration, which is expected to pave a new path for multifunctional implantable biomaterials with both therapeutic and regenerative functions.
- URI
- http://hanyang.dcollection.net/common/orgView/200000720928https://repository.hanyang.ac.kr/handle/20.500.11754/188571
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIOENGINEERING(생명공학과) > Theses (Master)
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