Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Cheon-Gyu Cho | - |
dc.contributor.author | 김효미 | - |
dc.date.accessioned | 2024-03-01T07:40:47Z | - |
dc.date.available | 2024-03-01T07:40:47Z | - |
dc.date.issued | 2024. 2 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000723394 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/188440 | - |
dc.description.abstract | We have investigated 3,5-dibromo-2-pyrone as a new synthetic starting point toward target-oriented synthesis, utilizing its peculiar reactivity as a neutral diene and the selective maneuverability of the two bromine groups. Such efforts have resulted in the successful synthesis of a series of biologically valuable natural products. Inspired by our recent success on internal hydrogen-bond mediated asymmetric DielsAlder reaction of 2-pyrones, we have launched a program to invent a new route that would allow efficient asymmetric synthesis of (-)-platensimycin. The key transformations include the C3-selective Sonogashira coupling reaction of 3,5-dibromo-2-pyrone, SmI2-mediated stereoselective reduction, and asymmetric intramolecular Diels-Alder cycloaddition reaction. Recent progress toward total synthesis of (-)-platensimycin is presented in this thesis. | - |
dc.publisher | 한양대학교 대학원 | - |
dc.title | Total synthesis of (-)-platensimycin by internal H-bond mediated intramolecular Diels-Alder reaction | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 김효미 | - |
dc.contributor.alternativeauthor | Hyo-Mi Kim | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 화학과 | - |
dc.description.degree | Doctor | - |
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