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Super-resolutionmicroscopystudyofthemechanismofplateletrelease
- Title
- Super-resolutionmicroscopystudyofthemechanismofplateletrelease
- Author
- 고석란
- Alternative Author(s)
- 고석란
- Advisor(s)
- 김두리
- Issue Date
- 2021.2
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- Asteadysupplyofplateletsmaintainstheirlevelsintheblood,andthisisachievedbythegenerationofprogenyfromplateletintermediates.Usingsystematicandintegrativesuper-resolutionmicroscopy,weexaminedtheultrastructuralorganizationofvariousorganellesindifferentplateletintermediatestounderstandthemechanismoforganelleredistributionandsorting,whichmayberequiredforplateletproduction.Weobservedthedynamicinterconversionbetweentheintermediatesviavariouspathwaysandfoundthatmicrotubuleswereresponsibleforcontrollingtheoverallshapeofplateletintermediates.Super-resolutionimagesshowedthatmostoftheorganelleswerelocatednearthecellperipheryinovalpreplateletsandconfinedtothebulboustipsinproplatelets.Wealsofoundthatthedistributionofthedensetubularsystemandα-granuleswasregulatedbyactin,whereasthatofmitochondriaanddensegranuleswasgovernedbymicrotubules.Altogether,ourresultscallforareassessmentoforganelleredistributioninplateletintermediates.
- URI
- http://hanyang.dcollection.net/common/orgView/200000485746https://repository.hanyang.ac.kr/handle/20.500.11754/188233
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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