Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승환 | - |
dc.date.accessioned | 2024-01-10T07:07:31Z | - |
dc.date.available | 2024-01-10T07:07:31Z | - |
dc.date.issued | 2023-12-22 | - |
dc.identifier.citation | ADVANCED FUNCTIONAL MATERIALS | en_US |
dc.identifier.issn | 1616-301X | en_US |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85171188204&origin=resultslist&sort=plf-f&src=s&sid=1a00458449e439f0171e741038cdd6f9&sot=b&sdt=b&s=TITLE-ABS-KEY%28Bioelectronic+Tongue+for+Identifying+and+Masking+Bitterness+Based+on+Bitter+Taste+Receptor+Agonism+and+Antagonism%29&sl=128&sessionSearchId=1a00458449e439f0171e741038cdd6f9&relpos=0 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/188112 | - |
dc.description.abstract | Bitterness elicits unpleasant sensations in humans, which can hinder the acceptance of foods and medication adherence. Therefore, identifying and masking bitter tastes is crucial for developing palatable foods and promoting medication compliance in the food and pharmaceutical industries. To achieve this, employing agonism and antagonism of bitter taste receptors as effective strategies at the molecular level is essential. In this study, a bioelectronic tongue is developed to characterize the agonism and antagonism of bitter taste receptors. The human bitter taste receptors hTAS2R16 and hTAS2R31 are produced using an Escherichia coli expression system and reconstituted into nanodiscs (NDs). Subsequently, hTAS2R16- and hTAS2R31-NDs are immobilized on the surface of graphene field-effect transistors (FETs) to construct bioelectronic tongues. The developed system sensitively detected the bitter agonists, salicin and saccharin, at concentrations as low as 100 fM, with high selectivity in real-time. The dose-dependent curves shifted and K values decreased by the antagonists of hTAS2R16 and hTAS2R31, indicating antagonism-based masking of bitter taste. Therefore, the developed bioelectronic tongue holds promise for identifying bitter tastes and evaluating the masking of bitterness based on the agonism and antagonism of hTAS2Rs. | en_US |
dc.description.sponsorship | J.Y.H., K.H.K., and S.E.S. contributed equally to this work. This work was supported by the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (MSIT) of Korea (No. 2021R1F1A1062909 and RS‐2023‐00240661) and the Ministry of Education (No. 2018R1A6A1A03024231). S.H.L. would like to acknowledge support from the Technology Innovation Program funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea) (No. 20008414); the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) and Korea Smart Farm R&D Foundation (KosFarm) through Smart Farm Innovation Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) and Ministry of Science and ICT(MSIT), Rural Development Administration(RDA) (421020‐03); the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF2021M3A9I5021439); Korea Ministry of Environment (MOE) through Technology Development Project for Safety Management of Household Chemical Products Program (or Project), funded by Korea Ministry of Environment (MOE)(2022002980005, 1485018893, Supporting Information, 1485018881). | en_US |
dc.language | en_US | en_US |
dc.publisher | John Wiley and Sons Inc | en_US |
dc.relation.ispartofseries | Volume 33, Issue 52;2304997 | - |
dc.subject | bitter taste masking | en_US |
dc.subject | bitter taste receptor | en_US |
dc.subject | field-effect transistor | en_US |
dc.subject | graphene; nanodiscs | en_US |
dc.title | Bioelectronic Tongue for Identifying and Masking Bitterness Based on Bitter Taste Receptor Agonism and Antagonism | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/adfm.202304997 | en_US |
dc.relation.page | 2304997-2304997 | - |
dc.relation.journal | ADVANCED FUNCTIONAL MATERIALS | - |
dc.contributor.googleauthor | Hwang, Jun Young | - |
dc.contributor.googleauthor | Kim, Kyung Ho | - |
dc.contributor.googleauthor | Seo, Sung Eun | - |
dc.contributor.googleauthor | Nam, Youngju | - |
dc.contributor.googleauthor | Jwa, Sanghee | - |
dc.contributor.googleauthor | Yang, Inwoo | - |
dc.contributor.googleauthor | Park, Tai Hyun | - |
dc.contributor.googleauthor | Kwon, Oh Seok | - |
dc.contributor.googleauthor | Lee, Seung Hwan | - |
dc.relation.code | 2023034916 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF BIONANO ENGINEERING | - |
dc.identifier.pid | vincero78 | - |
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