Nuclear mRNA Export and Aging
- Title
- Nuclear mRNA Export and Aging
- Author
- 안성훈
- Keywords
- mRNA export; TREX; TREX-2; NPC; lifespan; neurodegenerative diseases
- Issue Date
- 2022-05
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Citation
- International Journal of Molecular Sciences, v. 23, NO. 10, article no. 5451, Page. 1-12
- Abstract
- The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still poorly understood, although the nuclear events after transcription are coupled closely with the transcription pathway because the essential factors required for mRNA transport, namely TREX, TREX-2, and nuclear pore complex (NPC), physically and functionally interact with various transcription factors, including the activator/repressor and pre-mRNA processing factors. Dysregulation of the mediating factors for mRNA export from the nucleus generally leads to the aberrant accumulation of nuclear mRNA and further impairment in the vegetative growth and normal lifespan and the pathogenesis of neurodegenerative diseases. The optimal stoichiometry and density of NPC are destroyed during the process of cellular aging, and their damage triggers a defect of function in the nuclear permeability barrier. This review describes recent findings regarding the role of the nuclear mRNA export in cellular aging and age-related neurodegenerative disorders.
- URI
- https://www.scopus.com/record/display.uri?eid=2-s2.0-85129873691&origin=inward&txGid=1cc012892af6f10c41ffe064b664e0e4#indexed-keywordshttps://repository.hanyang.ac.kr/handle/20.500.11754/185155
- ISSN
- 1661-6596;1422-0067
- DOI
- 10.3390/ijms23105451
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
- Files in This Item:
- 86406_안성훈.pdfDownload
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