파킨슨병의 원인유전자와 연관된 자가포식현상

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative motor disorder, affecting approximately 1 % ofthe population aged ≥60 years. Recent investigations have shown that in addition to motor symptoms such asbradykinesia, resting tremor, and gait instability, PD also causes non-motor symptoms such as insomnia, constipation,depression, and dementia. Most PD cases occurred sporadically, but 5-10% is inherited as familial PD, and severalPD-causative genes have been identified and intensively studied. Autophagy is a self-degrading mechanism of balancingthe energy source in response to nutrient shortage and various stresses, and is a tightly regulated and complicatedprocess that generates double-membrane organelles. Autophagy failure has recently been observed in both animal PDmodels and human PD patients. The intention of this review is to introduce recent findings regarding the relationshipbetween causative genetic mutations in PD and autophagy, from a clinical perspective.