Azide-alkyne cycloaddition by recyclable heterogeneous Cu catalysts on reverse phase silica gel

Abstract

Functionalized reverse phase silica gel was synthesized as heterogeneous catalysts support. Cu(I) and Cu(II) catalysts immobilized onto two types of supports were prepared and characterized. The copper catalyzed azide-alkyne cycloaddition was performed in water via a one-pot reaction and yielded good results. And these catalysts were applied to azide-alkyne cycloaddition reaction of glycidyl azide polymer in DMSO. These catalysts are air stable and reusable over multiple uses.