Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정일엽 | - |
dc.date.accessioned | 2023-07-20T01:10:12Z | - |
dc.date.available | 2023-07-20T01:10:12Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | BMB Reports, v. 44, NO. 7, Page. 452-457 | - |
dc.identifier.issn | 1976-6696;1976-670X | - |
dc.identifier.uri | http://koreascience.or.kr/article/JAKO201123163432845.page | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183921 | - |
dc.description.abstract | The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), ER alpha and ER beta. ER alpha-induced Egr-1 expression has been extensively studied; however, the role of ER beta is yet not known. In the present study, we investigated whether or not ER beta induces Egr-1 expression in C6 rat glioma cells, which express ER beta but not ER alpha. Our results show that ER beta promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade. [BMB reports 2011; 44(7): 452-457] | - |
dc.description.sponsorship | This work was supported by the Disease Network Research Program (grant no. 20090084181) and Basic Science Research Program (KRF-2008-314-C00290) of the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology, Republic of Korea. This paper was supported by the SMART Research Professor Program of Konkuk University | - |
dc.language | en | - |
dc.publisher | 생화학분자생물학회 | - |
dc.subject | C6 glioma | - |
dc.subject | Egr-1 | - |
dc.subject | Estrogen receptor beta | - |
dc.subject | MAPK | - |
dc.subject | 17 beta-estradiol | - |
dc.title | Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells | - |
dc.type | Article | - |
dc.relation.no | 7 | - |
dc.relation.volume | 44 | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.7.452 | - |
dc.relation.page | 452-457 | - |
dc.relation.journal | BMB Reports | - |
dc.contributor.googleauthor | Kim, Ji-Ha | - |
dc.contributor.googleauthor | Chung, Il Yup | - |
dc.contributor.googleauthor | Lim, Yoongho | - |
dc.contributor.googleauthor | Lee, Young Han | - |
dc.contributor.googleauthor | Shin, Soon Young | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 의약생명과학과 | - |
dc.identifier.pid | iychu | - |
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