Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정일엽 | - |
dc.date.accessioned | 2023-07-20T01:07:12Z | - |
dc.date.available | 2023-07-20T01:07:12Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | Journal of Human Genetics, v. 57, NO. 4, Page. 247-253 | - |
dc.identifier.issn | 1434-5161;1435-232X | - |
dc.identifier.uri | https://www.nature.com/articles/jhg201212 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183916 | - |
dc.description.abstract | Aspirin-exacerbated respiratory diseases (AERD) are associated with the metabolism of arachidonic acid. FPR2 (formyl peptide receptor2) is a high-affinity ligand receptor for potent anti-inflammatory lipid metabolites: lipoxins. Thus, functional alterations of the FPR2 may contribute to AERD. We investigated the relationship between single-nucleotide polymorphisms (SNPs) in the FPR2 and AERD. Asthmatics were categorized into AERD <15% decreases in forced expiratory volume in one second (FEV1), and/or naso-ocular reactions after oral aspirin challenge (n=170) and aspirin-tolerant asthma (ATA, n=268). In all, 11 SNPs were genotyped. FPR2 protein expressions on CD14-positive monocytes in peripheral blood were measured using flow cytometric analysis. We performed RT-PCR of the FPR2 mRNA expressed by peripheral blood mononuclear cells. Logistic regression analysis showed that the minor allele frequency of FPR2-4209T>G (rs1769490) in intron 2 was significantly lower in the AERD group (n=170) than in the ATA group (n=268) (P=0.006, P-corr=0.04, recessive model). The decline of FEV1 after aspirin challenge was significantly lower in the subjects with GG homozygotes of FPR2-4209T>G than those with the other genotypes (P=0.0002). Asthmatic homozygotes for FPR2-4209T>G minor allele exhibited significantly higher FPR2 protein expression in CD14-positive monocytes than did those with the common allele of FPR2-4209T>G allele (P=0.01). There was no difference in the expression of the wild form and the exon 2 deleted variant form of FPR2 gene according to the genotypes of FPR2-4209T>G. The minor allele at FPR2-4209T>G may have a protective role against the development of AERD, via increase of FPR2 protein expression in inflammatory cells. Journal of Human Genetics (2012) 57, 247-253; doi:10.1038/jhg.2012.12; published online 1 March 2012 | - |
dc.description.sponsorship | DNA samples were generously provided by the Soonchunhyang University Bucheon Hospital Biobank, a member of the National Biobank of Korea, supported by the Ministry of Health, Welfare and Family Affairs, Republic of Korea. | - |
dc.language | en | - |
dc.publisher | Springer Verlag | - |
dc.subject | aspirin | - |
dc.subject | asthma | - |
dc.subject | FPR2 (formyl peptide receptor 2) | - |
dc.subject | SNPs (single-nucleotide polymorphisms) | - |
dc.title | Association analysis of formyl peptide receptor 2 (FPR2) polymorphisms and Aspirin exacerbated respiratory diseases | - |
dc.type | Article | - |
dc.relation.no | 4 | - |
dc.relation.volume | 57 | - |
dc.identifier.doi | 10.1038/jhg.2012.12 | - |
dc.relation.page | 247-253 | - |
dc.relation.journal | Journal of Human Genetics | - |
dc.contributor.googleauthor | Kim, Hee-Jeong | - |
dc.contributor.googleauthor | Cho, Sung-Hwan | - |
dc.contributor.googleauthor | Park, Jong-Sook | - |
dc.contributor.googleauthor | Lee, Tae-Hyeong | - |
dc.contributor.googleauthor | Lee, Eun-Ju | - |
dc.contributor.googleauthor | Kim, Yong-Hoon | - |
dc.contributor.googleauthor | Uh, Soo-Taek | - |
dc.contributor.googleauthor | Chung, Il Yup | - |
dc.contributor.googleauthor | Kim, Mi-Kyeong | - |
dc.contributor.googleauthor | Choi, Inseon S. | - |
dc.contributor.googleauthor | Park, Byung-Lae | - |
dc.contributor.googleauthor | Shin, Hyoung-Doo | - |
dc.contributor.googleauthor | Park, Choon-Sik | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 의약생명과학과 | - |
dc.identifier.pid | iychu | - |
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