Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성기훈 | - |
dc.date.accessioned | 2023-07-12T01:06:03Z | - |
dc.date.available | 2023-07-12T01:06:03Z | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 414, NO. 24, Page. 7191-7201 | - |
dc.identifier.issn | 1618-2642;1618-2650 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00216-022-04271-5 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/182847 | - |
dc.description.abstract | The generation of a mesoporous structure in platinum nanoparticles can effectively enhance physical and chemical properties. In this study, mesoporous platinum nanoparticles (MPNs) were synthesized by a soft template-mediated one-pot chemical method. To develop a mesoporous structure, Pluronic F-127 was employed. The Pluronic F-127 surfactant forms self-assembled micelles, and the micelles act as the pore-directing agents in the synthesis of nanoparticles. Scanning electron microscopy results revealed that the MPN had a uniform size of 70 nm on average and a distinct mesoporous structure. The development of a concave mesoporous structure on the surface of the MPNs can increase the surface area and facilitate the efficient transport of reactants. The synthesized MPNs exhibited peroxidase-like activity. Furthermore, the MPNs showed excellent catalytic efficiency compared to HRP, due to the high surface area derived from the presence of the mesoporous structure. The peroxidase-like MPNs were applied to the enzyme-linked immunosorbent assay (ELISA) of C-reactive protein (CRP). The MPN-based ELISA exhibited sensitive CRP detection in the range from 0.24 to 7.8 ng/mL with a detection limit of 0.13 ng/mL. Moreover, the recoveries of the CRP concentrations in spiked human serum were 98.6% and 102%. These results demonstrate that as a peroxidase mimic, the MPNs can replace the natural enzymes in conventional ELISA for sensitive CRP detection. | - |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea (2018R1A6A1A03024231 and 2021R1A2C1003566). | - |
dc.language | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | Mesoporous nanoparticle | - |
dc.subject | Nanozyme | - |
dc.subject | Colorimetric detection | - |
dc.subject | C-Reactive protein | - |
dc.subject | Enzyme-linked immunosorbent assay | - |
dc.title | Mesoporous platinum nanoparticles as a peroxidase mimic for the highly sensitive determination of C-reactive protein | - |
dc.type | Article | - |
dc.relation.no | 24 | - |
dc.relation.volume | 414 | - |
dc.identifier.doi | 10.1007/s00216-022-04271-5 | - |
dc.relation.page | 7191-7201 | - |
dc.relation.journal | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | - |
dc.contributor.googleauthor | Son, Seong Eun | - |
dc.contributor.googleauthor | Gupta, Pramod K. | - |
dc.contributor.googleauthor | Hur, Won | - |
dc.contributor.googleauthor | Lee, Han Been | - |
dc.contributor.googleauthor | Park, Yosep | - |
dc.contributor.googleauthor | Park, Jiyeon | - |
dc.contributor.googleauthor | Kim, Seong Nyeon | - |
dc.contributor.googleauthor | Seong, Gi Hun | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 생명나노공학과 | - |
dc.identifier.pid | ghseong | - |
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