Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이상훈 | - |
dc.contributor.author | 김성훈 | - |
dc.date.accessioned | 2023-06-29T16:00:55Z | - |
dc.date.available | 2023-06-29T16:00:55Z | - |
dc.date.issued | 2020. 8 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000438287 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/182552 | - |
dc.description.abstract | Parkinson's disease (PD) is an age-related neurodegenerative disease that accompanies motor symptoms, characterized by loss of dopaminergic (DA) neurotransmission in substantia nigra pars compacta of the midbrain. Also, a pathologic hallmark of PD is intra-neuronal the accumulation of alpha-synuclein (α-syn) aggregates, called Lewy body and Lewy neurites. The α-syn aggregate is suggested as an important key target in neurodegeneration in Parkinson's or other neurodegenerative diseases. While much research is being done on α-syn for the treatment of PD, no therapeutic intervention to effectively relieve α-synuclinopathy has been developed. In this study, I provide evidences that cultured astrocytes, especially those derived from ventral midbrain (VM) where mDA neurons are developed and reside, exerted therapeutic actions to reduce α-synucleinopathy in neuronal cells by regulating a series of procedures associated with formation and transmission of toxic α-syn aggregates. Based on these findings, I propose that astrocyte conditioned media could be a promising source for PD drug discovery and astrocyte could be a candidate supporting cell source for stem cell-based PD therapy which is free from the host-to-graft propagation of toxic α-syn. | - |
dc.publisher | 한양대학교 | - |
dc.title | Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease | - |
dc.type | Theses | - |
dc.contributor.googleauthor | Seong-Hoon Kim | - |
dc.contributor.alternativeauthor | 김성훈 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 의생명공학전문대학원 | - |
dc.sector.department | 의생명과학과 | - |
dc.description.degree | Master | - |
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