Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 황승용 | - |
dc.date.accessioned | 2023-05-31T01:38:55Z | - |
dc.date.available | 2023-05-31T01:38:55Z | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | Life Sciences, v. 81, NO. 25-26, Page. 1638-1644 | - |
dc.identifier.issn | 0024-3205;1879-0631 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0024320507007692?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/181685 | - |
dc.description.abstract | Differentiation-inducing therapy by agents such as 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] represents a useful approach for the treatment for cancer, including acute myeloid leukemia (AML). Recent studies demonstrated that the combined administration of 1,25-(OH)(2)D-3 and differentiation-enhancing agents could alleviate the side effects of 1,25-(OH)(2)D-3 and improve the rate of long term survival. In this study, we determined the enhancing activities of ceramide derivatives on 1,25-(OH)(2)D-3-induced differentiation of human myeloid leukemia HL-60 cells. Importantly, some of these derivatives-namely, A2, B3, and H9-enhanced the 1,25-(OH)(2)D-3-induced differentiation of HL-60 cells in a concentration-dependent manner. In addition, the morphologic studies using Giemsa staining and flow cytometric analysis demonstrated that the combined treatment of 1,25-(OH)(2)D-3 with one of the three analogues, A2, B3, and H9, directed the HL-60 cells into monocytic lineage, but not into granulocytic lineage. The inhibition studies demonstrated that A2, B3, and H9, enhanced 1,25-(OH)(2)D-3-induced differentiation of HL-60 cells via the PI3-K/PKC/JNK/ERK pathways. The ability of ceramide derivatives to enhance the differentiation-inducing potential of 1,25-(OH)(2)D-3 may contribute to an effective therapy for AML. (C) 2007 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (01-PJ10-PG6-01GN16-000 | - |
dc.language | en | - |
dc.publisher | Elsevier BV | - |
dc.subject | ceramide library | - |
dc.subject | differentiation | - |
dc.subject | leukemia | - |
dc.subject | 1,25-dihydroxyvitamin D-3 | - |
dc.title | Enhancing effects of ceramide derivatives on 1,25-dihydroxyvitamin D-3-induced differentiation of human HL-60 leukemia cells | - |
dc.type | Article | - |
dc.relation.no | 25-26 | - |
dc.relation.volume | 81 | - |
dc.identifier.doi | 10.1016/j.lfs.2007.09.035 | - |
dc.relation.page | 1638-1644 | - |
dc.relation.journal | Life Sciences | - |
dc.contributor.googleauthor | Kim, Dong Soo | - |
dc.contributor.googleauthor | Kim, Seung Hyun | - |
dc.contributor.googleauthor | Song, Ju Han | - |
dc.contributor.googleauthor | Chang, Young-Tae | - |
dc.contributor.googleauthor | Hwang, Seung Yong | - |
dc.contributor.googleauthor | Kim, Tae Sung | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 의약생명과학과 | - |
dc.identifier.pid | syhwang | - |
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