Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황승용 | - |
dc.date.accessioned | 2023-05-31T00:13:10Z | - |
dc.date.available | 2023-05-31T00:13:10Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | BioChip Journal, v. 11, NO. 2, Page. 109-115 | - |
dc.identifier.issn | 1976-0280;2092-7843 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs13206-016-1203-7 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/181574 | - |
dc.description.abstract | This paper presents a proof-of-concept microfluidic aptamer-based sensor for thrombin point of -care testing using electrochemical impedance spectroscopy. The disposable biosensor is composed of a polydimethylsiloxane (PDMS) channel layer over a glass substrate. The substrate surface has an Au working electrode and a Pt reference/counter electrode. In this study, human thrombin was used as a biomarker for disease diagnosis. An unlabeled aptamer specific to thrombin was immobilized on a working electrode and electrochemical impedance was measured as thrombin was injected into the biosensor. Thrombin was detected by measuring change in impedance. The proposed biochip had a detection range of 0.1-100,000 ng mL(-1) for thrombin concentration and a limit of detection of 0.1 ng mL(-1). The results indicated that our biochip could be an effective tool for other molecular diagnostic systems. | - |
dc.language | en | - |
dc.publisher | 한국바이오칩학회 | - |
dc.subject | DNA Aptamer | - |
dc.subject | Microfluidics | - |
dc.subject | Thrombin | - |
dc.subject | Electrochemical impedance spectroscopy | - |
dc.subject | Anti-thrombin aptamer | - |
dc.title | Microfluidic Biochips for Simple Impedimetric Detection of Thrombin Based on Label-free DNA Aptamers | - |
dc.type | Article | - |
dc.relation.no | 2 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1007/s13206-016-1203-7 | - |
dc.relation.page | 109-115 | - |
dc.relation.journal | BioChip Journal | - |
dc.contributor.googleauthor | Limi, Taemin | - |
dc.contributor.googleauthor | Lee, Seung Yong | - |
dc.contributor.googleauthor | Yang, Jeongsuong | - |
dc.contributor.googleauthor | Hwang, Seung Yong | - |
dc.contributor.googleauthor | Ahn, Yoomin | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 의약생명과학과 | - |
dc.identifier.pid | syhwang | - |
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