Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정영희 | - |
dc.date.accessioned | 2023-04-28T06:37:21Z | - |
dc.date.available | 2023-04-28T06:37:21Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, v. 95, no. 17, page. E2354-E2365 | en_US |
dc.identifier.issn | 0028-3878; 1526-632X | en_US |
dc.identifier.uri | https://n.neurology.org/content/95/17/e2354 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/179370 | - |
dc.description.abstract | Objective To investigate the association between APOE genotype and beta-amyloid (A beta) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI). Methods This was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of APOE genotype or diagnostic group on A beta positivity, we performed multivariate logistic regression analyses. Further distinctive underlying features of latent subgroups were examined by employing a latent class cluster analysis approach. Results In comparison with epsilon 3 homozygotes, in the ADCI group, epsilon 2 carriers showed a lower frequency of A beta positivity (odds ratio [OR] 0.43, 95% confidence interval [CI] 0.23-0.79), while in the SVCI group, epsilon 2 carriers showed a higher frequency of A beta positivity (OR 2.26, 95% CI 1.02-5.01). In particular, we observed an interaction effect of epsilon 2 carrier status and diagnostic group on A beta positivity (OR 5.12, 95% CI 1.93-13.56), in that relative to epsilon 3 homozygotes, there were more A beta-positive epsilon 2 carriers in the SVCI group than in the ADCI group. We also identified latent subgroups of A beta-positive APOE epsilon 2 carriers with SVCI and A beta-positive APOE epsilon 4 carriers with ADCI. Conclusions Our findings suggest that APOE epsilon 2 is distinctly associated with A beta deposition in patients with SVCI and those with ADCI. Our findings further suggest that there is a distinctive subgroup of A beta-positive APOE epsilon 2 carriers with SVCI among patients with cognitive impairment. | en_US |
dc.description.sponsorship | This research was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI19C1132); by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2016M3C7A1913844); by a fund (2018-ER6203-02) by Research of Korea Centers forDisease Control and Prevention; by the Brain Research Programof the NRF funded by the Ministry of Science & ICT (NRF-2018M3C7A1056512); by the National Research Council of Science & Technology (NST) grant by the Korea government (MSIP) (No. CRC-15-04-KIST). | en_US |
dc.language | en | en_US |
dc.publisher | WILEY | en_US |
dc.title | Association between APOE «2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1212/WNL.0000000000010811 | en_US |
dc.relation.journal | ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | - |
dc.contributor.googleauthor | Lee, Jin San | - |
dc.contributor.googleauthor | Lee, Hyejoo | - |
dc.contributor.googleauthor | Park, Seongbeom | - |
dc.contributor.googleauthor | Choe, Yeongsim | - |
dc.contributor.googleauthor | Park, Yu Hyun | - |
dc.contributor.googleauthor | Cheon, Bo Kyoung | - |
dc.contributor.googleauthor | Hahn, Alice | - |
dc.contributor.googleauthor | Ossenkoppele, Rik | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Jung, Young Hee | - |
dc.relation.code | 2020054131 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | neophilia | - |
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