Association between APOE «2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment
- Title
- Association between APOE «2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment
- Author
- 정영희
- Issue Date
- 2020-09
- Publisher
- WILEY
- Citation
- ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, v. 95, no. 17, page. E2354-E2365
- Abstract
- Objective
To investigate the association between APOE genotype and beta-amyloid (A beta) burden, as measured by PET in patients with subcortical vascular cognitive impairment (SVCI) and those with Alzheimer disease-related cognitive impairment (ADCI).
Methods
This was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of APOE genotype or diagnostic group on A beta positivity, we performed multivariate logistic regression analyses. Further distinctive underlying features of latent subgroups were examined by employing a latent class cluster analysis approach.
Results
In comparison with epsilon 3 homozygotes, in the ADCI group, epsilon 2 carriers showed a lower frequency of A beta positivity (odds ratio [OR] 0.43, 95% confidence interval [CI] 0.23-0.79), while in the SVCI group, epsilon 2 carriers showed a higher frequency of A beta positivity (OR 2.26, 95% CI 1.02-5.01). In particular, we observed an interaction effect of epsilon 2 carrier status and diagnostic group on A beta positivity (OR 5.12, 95% CI 1.93-13.56), in that relative to epsilon 3 homozygotes, there were more A beta-positive epsilon 2 carriers in the SVCI group than in the ADCI group. We also identified latent subgroups of A beta-positive APOE epsilon 2 carriers with SVCI and A beta-positive APOE epsilon 4 carriers with ADCI.
Conclusions
Our findings suggest that APOE epsilon 2 is distinctly associated with A beta deposition in patients with SVCI and those with ADCI. Our findings further suggest that there is a distinctive subgroup of A beta-positive APOE epsilon 2 carriers with SVCI among patients with cognitive impairment.
- URI
- https://n.neurology.org/content/95/17/e2354https://repository.hanyang.ac.kr/handle/20.500.11754/179370
- ISSN
- 0028-3878; 1526-632X
- DOI
- 10.1212/WNL.0000000000010811
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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