Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Wook Hong | - |
dc.date.accessioned | 2023-01-04T01:53:40Z | - |
dc.date.available | 2023-01-04T01:53:40Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, v. 142, Page. 290-296 | - |
dc.identifier.issn | 0927-7765;1873-4367 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776516300406?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178666 | - |
dc.description.abstract | Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | Iron oxide nanoparticles | - |
dc.subject | Mycophenolic acid | - |
dc.subject | Immunosuppressive drug | - |
dc.subject | Magnetic resonance imaging | - |
dc.subject | Drug delivery | - |
dc.title | Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles | - |
dc.type | Article | - |
dc.relation.volume | 142 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2016.01.040 | - |
dc.relation.page | 290-296 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Hwang, Jangsun | - |
dc.contributor.googleauthor | Lee, Eunwon | - |
dc.contributor.googleauthor | Kim, Jieun | - |
dc.contributor.googleauthor | Seo, Youngmin | - |
dc.contributor.googleauthor | Lee, Kwan Hong | - |
dc.contributor.googleauthor | Hong, Jong Wook | - |
dc.contributor.googleauthor | Gilad, Assaf A. | - |
dc.contributor.googleauthor | Park, Hansoo | - |
dc.contributor.googleauthor | Choi, Jonghoon | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 생명나노공학과 | - |
dc.identifier.pid | jwh | - |
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