Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2022-12-09T07:20:54Z | - |
dc.date.available | 2022-12-09T07:20:54Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | BIOMEDICINES, v. 10, NO. 1, article no. 96, Page. 1-26 | en_US |
dc.identifier.issn | 2227-9059 | en_US |
dc.identifier.uri | https://www.mdpi.com/2227-9059/10/1/96 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178136 | - |
dc.description.abstract | The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood–brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM. | en_US |
dc.description.sponsorship | This research was funded by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning, grant number NRF-2020R1A2C3005834. | en_US |
dc.language | en | en_US |
dc.publisher | MDPI | en_US |
dc.source | 83607_이동윤.pdf | - |
dc.subject | Blood–brain barrier (BBB) | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Glioblastoma multiform (GBM) | en_US |
dc.subject | Photodynamic therapy (PDT) | en_US |
dc.subject | Photosensitizer (PS) | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Reactive oxygen species (ROS) | en_US |
dc.subject | Surgical resection | en_US |
dc.subject | Targeted therapy | en_US |
dc.subject | Tumor microenvironment | en_US |
dc.title | Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.3390/biomedicines10010096 | en_US |
dc.relation.page | 1-26 | - |
dc.relation.journal | BIOMEDICINES | - |
dc.contributor.googleauthor | Kim, Hyung Shik | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 생명공학과 | - |
dc.identifier.pid | dongyunlee | - |
dc.identifier.orcid | https://orcid.org/0000-0001-7691-0447 | - |
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