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3D Printing of dynamic tissue scaffold by combining self-healing hydrogel and self-healing ferrogel

Title
3D Printing of dynamic tissue scaffold by combining self-healing hydrogel and self-healing ferrogel
Author
이근용
Keywords
3D printing; Ferrogel; Glycol chitosan; Hydrogel; Oxidized hyaluronate; Self-healing
Issue Date
2021-12
Publisher
Elsevier B.V.
Citation
Colloids and Surfaces B: Biointerfaces, v. 208, article no. 112108, Page. 1-8
Abstract
Hydrogels have been widely utilized in tissue engineering applications as functional and biological synthetic extracellular matrices (ECMs) can be created with gels. However, typical hydrogels cannot be exploited in 3D printing, especially in extrusion printing, unless post-cross-linking after printing is provided. Additionally, dynamic tissue scaffolds that can mimic ECM environments in the body have been demonstrated to be useful in tissue engineering. Here, we hypothesized that a 3D-printed dynamic tissue scaffold could be fabricated by combining self-healing hydrogel and self-healing ferrogel without post-cross-linking, which could be useful for the regulation of cell phenotype under magnetic stimulation. Hydrogels were formed from oxidized sodium hyaluronate and glycol chitosan, and adipic acid dihydrazide was additionally utilized for self-healing behavior of the gel. Superparamagnetic iron oxide nanoparticles (SPIONs) were also used to prepare a magnetically responsive hydrogel system (i.e., ferrogel). Physicochemical properties, cytotoxicity, and printability of the self-healing hydrogel/ferrogel system fabricated by a 3D printing process, were investigated. Dimensional changes in a tissue scaffold were achieved by the application of a magnetic field. Interestingly, chondrogenic differentiation of ATDC5 cells cultured within the dynamic tissue scaffold was enhanced by applying a magnetic field in vitro. This approach may be useful for fabricating dynamic tissue scaffolds by a 3D printing method for tissue engineering applications.
URI
https://www.sciencedirect.com/science/article/pii/S092777652100552X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/178129
ISSN
0927-7765;1873-4367
DOI
10.1016/j.colsurfb.2021.112108
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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