Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2022-12-09T07:04:14Z | - |
dc.date.available | 2022-12-09T07:04:14Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | MATHEMATICAL BIOSCIENCES, v. 334, article no. 108520 | en_US |
dc.identifier.issn | 0025-5564;1879-3134 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0025556420301620?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178123 | - |
dc.description.abstract | A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by uninfected cells is described by an infectivity parameter, which is inferred from available experimental data. The parameter is also able to describe the effects of changes in the tumour environment that affect viral uptake from tumour cells. Results show that when a virus is inoculated inside a growing tumour, strategies for enhancing infectivity do not lead to a complete eradication of the tumour. Within typical times of experiments and treatments, we observe the onset of oscillations, which always prevent a full destruction of the tumour mass. These findings are in good agreement with available laboratory results. Further analysis shows why a fully successful therapy cannot exist for the proposed model and that care must be taken when designing and engineering viral vectors with enhanced features. In particular, bifurcation analysis reveals that creating longer lasting virus particles or using strategies for reducing infected cell lifespan can cause unexpected and unwanted surges in the overall tumour load over time. Our findings suggest that virotherapy alone seems unlikely to be effective in clinical settings unless adjuvant strategies are included. | en_US |
dc.description.sponsorship | The authors gratefully acknowledge support for this work through the Australian Government Research Training Program Scholarship (PP) and the Australian Research Council Discovery Project DP180101512 (PSK, FF). | en_US |
dc.language | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Oncolytic virotherapy | en_US |
dc.subject | PDEs | en_US |
dc.subject | ODEs | en_US |
dc.subject | Bifurcation theory | en_US |
dc.title | The role of viral infectivity in oncolytic virotherapy outcomes: A mathematical study | en_US |
dc.type | Article | en_US |
dc.relation.volume | 334 | - |
dc.identifier.doi | 10.1016/j.mbs.2020.108520 | en_US |
dc.relation.journal | MATHEMATICAL BIOSCIENCES | - |
dc.contributor.googleauthor | Pooladvand, Pantea | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Yoon, A-Rum | - |
dc.contributor.googleauthor | Kim, Peter S. | - |
dc.contributor.googleauthor | Frascoli, Federico | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 생명공학과 | - |
dc.identifier.pid | chaeok | - |
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