Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류성언 | - |
dc.date.accessioned | 2022-12-09T05:19:12Z | - |
dc.date.available | 2022-12-09T05:19:12Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 78, Page. 265-269 | en_US |
dc.identifier.issn | 2053-230X | en_US |
dc.identifier.uri | https://scripts.iucr.org/cgi-bin/paper?S2053230X22006173 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178089 | - |
dc.description.abstract | Receptor-type protein tyrosine phosphatases (RPTPs) receive extracellular stimuli and transfer them into cells. They regulate cell growth, differentiation and death via specific signals. They have also been implicated in cancer, diabetes and neurological diseases. RPTPH, a member of the type 3 RPTP (R3-PTP) family, is an important regulator of colorectal cancer and hepatic carcinoma. Despite its importance in drug development, the structure of RPTPH has not yet been resolved. Here, the crystal structure of the catalytic domain of RPTPH was determined at 1.56 angstrom resolution. Despite similarities to other R3-PTPs in its overall structure, RPTPH exhibited differences in its loop regions and side-chain conformations. Compared with other R3-PTPs, RPTPH has unique side chains near its active site that may confer specificity for inhibitor binding. Therefore, detailed information on the structure of RPTPH provides clues for the development of specific inhibitors. | en_US |
dc.description.sponsorship | This work was supported by biomedical technology development projects of National Research Foundation, Korea (NRF2015M3A9B5030302 and NRF-2021M3A9G8024747). | en_US |
dc.language | en | en_US |
dc.publisher | INT UNION CRYSTALLOGRAPHY | en_US |
dc.subject | human RPTPH | en_US |
dc.subject | crystal structure | en_US |
dc.subject | specific inhibitor development | en_US |
dc.subject | loop conformation | en_US |
dc.subject | colorectal cancer | en_US |
dc.subject | hepatic carcinoma | en_US |
dc.title | Crystal structure of the catalytic domain of human RPTPH | en_US |
dc.type | Article | en_US |
dc.relation.volume | 78 | - |
dc.identifier.doi | 10.1107/S2053230X22006173 | en_US |
dc.relation.page | 265-269 | - |
dc.relation.journal | ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | - |
dc.contributor.googleauthor | Kim, Myeongbin | - |
dc.contributor.googleauthor | Ryu, Seong Eon | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 생명공학과 | - |
dc.identifier.pid | ryuse | - |
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