Unleashing cell-penetrating peptide applications for immunotherapy
- Title
- Unleashing cell-penetrating peptide applications for immunotherapy
- Author
- 최제민
- Issue Date
- 2022-06
- Publisher
- Elsevier Ltd
- Citation
- Trends in Molecular Medicine, v. 28, NO. 6, Page. 482-496
- Abstract
- With the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also discuss their challenges and opportunities for preclinical studies in various immune diseases. CPP conjugation to antigenic peptides or proteins can enable efficient antigen uptake and cross-presentation by antigen-presenting cells (APCs), which induce both humoral and cytotoxic responses. In addition, CPP-coupled immune modulators can enhance antitumor immunity or anti-inflammatory effects to regulate allergies and autoimmunity. Given their huge advantages in overcoming delivery barriers, CPP-based strategies for immunomodulation could extend drug optimization and advance immunotherapy in various human diseases.
- URI
- https://www.sciencedirect.com/science/article/pii/S1471491422000788?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/177925
- ISSN
- 1471-4914;1471-499X
- DOI
- 10.1016/j.molmed.2022.03.010
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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