Immune Checkpoint Blockades in Triple-Negative Breast Cancer: Current State and Molecular Mechanisms of Resistance
- Title
- Immune Checkpoint Blockades in Triple-Negative Breast Cancer: Current State and Molecular Mechanisms of Resistance
- Author
- 이경민
- Keywords
- immune checkpoint blockade; resistance; TNBC
- Issue Date
- 2022-05
- Publisher
- MDPI
- Citation
- Biomedicines, v. 10, NO. 5, article no. 1130, Page. 1-17
- Abstract
- Immune checkpoint blockades (ICBs) have revolutionized cancer treatment. Recent studies have revealed a subset of triple-negative breast cancer (TNBC) to be considered as an immunogenic breast cancer subtype. Characteristics of TNBC, such as higher mutation rates and number of tumor-infiltrating immune cells, render the immunogenic phenotypes. Consequently, TNBCs have shown durable responses to ICBs such as atezolizumab and pembrolizumab in clinic. However, a significant number of TNBC patients do not benefit from these therapies, and mechanisms of resistance are poorly understood. Here, we review biomarkers that predict the responsiveness of TNBCs to ICB and recent advances in delineating molecular mechanisms of resistance to ICBs.
- URI
- https://www.mdpi.com/2227-9059/10/5/1130https://repository.hanyang.ac.kr/handle/20.500.11754/177899
- ISSN
- 2227-9059;2227-9059
- DOI
- 10.3390/biomedicines10051130
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
- Files in This Item:
- Immune Checkpoint Blockades in Triple-Negative Breast Cancer Current State and Molecular Mechanisms of Resistance.pdfDownload
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