Host-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment
- Title
- Host-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment
- Author
- 양철수
- Keywords
- Tuberculosis; Mycobacterium tuberculosis; multidrug resistance; host-directed therapeutics; immunomodulatory regulator
- Issue Date
- 2017-09
- Publisher
- 한국미생물·생명공학회
- Citation
- Journal of Microbiology and Biotechnology, v. 27.0, NO. 9, Page. 1549-1558
- Abstract
- Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a prevalent infectious disease worldwide owing to the limitations of current TB therapeutic regimens. Recent work on novel TB treatment strategies has suggested that directly targeting host factors may be beneficial for TB treatment. Such strategies, termed host-directed therapeutics (HDTs), focus on host-pathogen interactions. HDTs may be more effective than the currently approved TB drugs, which are limited by the long durations of treatment needed and the emergence of drug-resistant strains. Targets of HDTs include host factors such as cytokines, immune checkpoints, immune cell functions, and essential enzyme activities. This review article discusses examples of potentially promising HDTs and introduces novel approaches for their development.
- URI
- https://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1705.05032https://repository.hanyang.ac.kr/handle/20.500.11754/177553
- ISSN
- 1017-7825;1738-8872
- DOI
- 10.4014/jmb.1705.05032
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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