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Oxidative stress, growth inhibition, and DNA damage in earthworms induced by the combined pollution of typical neonicotinoid insecticides and heavy metals

Title
Oxidative stress, growth inhibition, and DNA damage in earthworms induced by the combined pollution of typical neonicotinoid insecticides and heavy metals
Author
김영모
Keywords
Eisenia fetida; Oxidative damage; Histopathology; Comet assay; Uniform design; Multiple regressions
Issue Date
2021-02
Publisher
ELSEVIER
Citation
SCIENCE OF THE TOTAL ENVIRONMENT, v. 754, article no. 141873
Abstract
Heavy metals pollution of soil and widespread application of neonicotinoid insecticides have caused environmental problems worldwide. To evaluate ecological toxicity resulting from the combined pollution of neonicotinoids and heavy metals, typical representatives of neonicotinoid insecticides (imidacloprid, thiamethoxam, dinotefuran) and heavy metals (cadmium, copper, zinc) were selected as soil pollutants; earthworms were used as test organisms. Analysis of the main and interaction effects of a combined pollution process were performed using a uniform design method. Results showed that the reactive oxygen species (ROS) content of earthworms in most treatment groups was higher during exposure than that of the control group. The malondialdehyde (MDA) and ROS content of earthworms demonstrated relatively low values on the 21st day and increased by the 28th day. The interaction between dinotefuran and Cd had significant antagonistic effects on ROS and MDA. The combined pollution adversely affected both the growth and genes of earthworms and also caused damage to the epidermis, midgut, and DNA. The interaction between imidacloprid and Cd was synergistic to ROS, weight inhibition rate, and Olive tail moment (OTM), but was antagonistic to MDA. Of all the single and combined exposures, Zn as a single chemical affected ROS and DNA damage the most, and MDA was significantly enhanced by imidacloprid. Composite pollutants may create different primary effects and interactions causing potential harm to soil organisms.
URI
https://www.sciencedirect.com/science/article/pii/S0048969720354024?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/176304
ISSN
0048-9697 ; 1879-1026
DOI
10.1016/j.scitotenv.2020.141873
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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