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Oxidative stress and DNA damage in earthworm (Eisenia fetida) induced by triflumezopyrim exposure

Title
Oxidative stress and DNA damage in earthworm (Eisenia fetida) induced by triflumezopyrim exposure
Author
김영모
Keywords
Triflumezopyrim; Antioxidant enzyme; DNA damage; Earthworm
Issue Date
2021-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
CHEMOSPHERE, v. 264, Part 2, article no. 128499
Abstract
Triflumezopyrim is an excellent pesticide for preventing and controlling rice planthoppers. It is widely used in the production of field rice and mainly through spraying with some inadvertent loss of pesticide to the soil. The future may bring development and utilization of seeds containing triflumezopyrim which will certainly impact earthworms. To evaluate the toxic effects of triflumezopyrim on earthworms, reactive oxygen species (ROS), superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde content (MDA), glutathione S-transferase (GST), and DNA oxidative damage (8-hydroxy-2'-deoxyguanosine, 8-OHdG) were measured after 7, 14, 21, and 28 d analyzing the effects of 6 concentrations (0, 0.5, 1, 2.5, 5 and 10 mg/kg) of triflumezopyrim, respectively. ROS content did not change significantly in the early stages but showed a significant dose-effect relationship in the late stages. Antioxidant enzymes were activated in most treatment groups, and catalase activity was the same as that in the control group at 28 d. GST activity showed a trend of increasing first and then decreasing whereas MDA content had no obvious change in trend. 8-OHdG showed significant positive correlation with the concentration of triflumezopyrim at 28 d, indicating that the degree of DNA oxidative damage increased accordingly. The results showed that chronic exposure of triflumezopyrim may cause both oxidative stress and DNA damage in earthworms and alter the activity of antioxidant enzymes.
URI
https://www.sciencedirect.com/science/article/pii/S0045653520326941?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/176298
ISSN
0045-6535; 1879-1298
DOI
10.1016/j.chemosphere.2020.128499
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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