Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장용우 | - |
dc.date.accessioned | 2022-11-04T01:14:04Z | - |
dc.date.available | 2022-11-04T01:14:04Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 53, no. 1, page. 19-29 | en_US |
dc.identifier.issn | 1226-3613; 2092-6413 | en_US |
dc.identifier.uri | https://www.nature.com/articles/s12276-021-00555-5 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/176280 | - |
dc.description.abstract | Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its structural conformation changing more than twice on the microsecond-to-millisecond timescale. This observation suggests the possibility that certain ligands are able to squeeze into this narrow space, inducing a conformational change to create an accessible cavity. The cocrystallographic structure of Nurr1 bound to endogenous ligands such as prostaglandin E1/A1 and 5,6-dihydroxyindole contributed to clarifying the crucial roles of Nurr1 and opening new avenues for therapeutic interventions for neurodegenerative and/or inflammatory diseases related to Nurr1. This review introduces novel endogenous and synthetic Nurr1 agonists and discusses their potential effects in Nurr1-related diseases. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2018, 201800000003221). | en_US |
dc.language | en | en_US |
dc.publisher | SPRINGERNATURE | en_US |
dc.title | Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s12276-021-00555-5 | en_US |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Jang, Yongwoo | - |
dc.contributor.googleauthor | Kim, Woori | - |
dc.contributor.googleauthor | Leblanc, Pierre | - |
dc.contributor.googleauthor | Kim, Chun-Hyung | - |
dc.contributor.googleauthor | Kim, Kwang-Soo | - |
dc.relation.code | 2021000145 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | ywjang | - |
dc.identifier.researcherID | Y-9854-2018 | - |
dc.identifier.orcid | https://orcid.org/0000-0003-1574-9009 | - |
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