Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김상헌 | - |
dc.date.accessioned | 2022-11-02T02:41:06Z | - |
dc.date.available | 2022-11-02T02:41:06Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, v. 9, NO 2, Page. 929-936 | en_US |
dc.identifier.issn | 2213-2198; 2213-2201 | en_US |
dc.identifier.uri | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S2213219820309582?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213219820309582%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.webofscience.com%2F | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/176202 | - |
dc.description.abstract | Background Because severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) rarely occur, clinical data based on large-scale studies are still lacking. Objective To provide information on culprit drugs and clinical characteristics, including morbidity and mortality of SCARs based on a nationwide registry. Methods SCAR cases that occurred from 2010 to 2015 were recruited to the Korean SCAR registry from 34 tertiary referral hospitals. Demographics, causative drugs, causality, and clinical outcomes were collected by reviewing the medical record. Results A total of 745 SCAR cases (384 SJS/TEN cases and 361 DRESS cases) due to 149 drugs were registered. The main causative drugs were allopurinol (14.0%), carbamazepine (9.5%), vancomycin (4.7%), and antituberculous agents (6.3%). A strong preference for SJS/TEN was observed in carbonic anhydrase inhibitors (100%), nonsteroidal anti-inflammatory drugs (84%), and acetaminophen (83%), whereas dapsone (100%), antituberculous agents (81%), and glycopeptide antibacterials (78%) were more likely to cause DRESS. The mortality rate was 6.6% (SJS/TEN 8.9% and DRESS 4.2%). The median time to death was 19 days and 29 days in SJS/TEN and DRESS respectively, and 89.8% of deaths occurred within 60 days after the onset of the skin symptoms. Conclusion Allopurinol, carbamazepine, vancomycin, and antituberculous agents were the leading causes of SCARs in Korea. Some drugs preferentially caused a specific phenotype. The mortality rate of SCARs was 6.6%, and most of the deaths occurred within 2 months. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Academy of Asthma, Allergy, and Clinical Immunology and a grant from the Ministry of Food and Drug Safety of Korea ( 20182 MFDS445 ), and a grant from the Ministry of Food and Drug Safety to the Regional Pharmacovigilance Center in 2018. | en_US |
dc.language | en | en_US |
dc.publisher | ELSEVIER | en_US |
dc.subject | Drug-related side effects and adverse reactions; Stevens-Johnson syndrome; Drug hypersensitivity syndrome; Registries; Republic of Korea | en_US |
dc.title | A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1016/j.jaip.2020.09.011 | en_US |
dc.relation.page | 929-929 | - |
dc.relation.journal | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | - |
dc.contributor.googleauthor | Kang, Dong Yoon | - |
dc.contributor.googleauthor | Yun, James | - |
dc.contributor.googleauthor | Lee, Suh-Young | - |
dc.contributor.googleauthor | Koh, Young-Il | - |
dc.contributor.googleauthor | Sim, Da Woon | - |
dc.contributor.googleauthor | Kim, Sujeong | - |
dc.contributor.googleauthor | Nam, Young Hee | - |
dc.contributor.googleauthor | Park, Jung-Won | - |
dc.contributor.googleauthor | Kim, Sae Hoon | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.relation.code | 2021003158 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sangheonkim | - |
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