Repository at Hanyang UniversityCOLLEGE OF ENGINEERING SCIENCES[E](공학대학)BIONANO ENGINEERING(생명나노공학과)Articles
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dc.contributor.author채필석-
dc.date.accessioned2022-10-31T01:12:46Z-
dc.date.available2022-10-31T01:12:46Z-
dc.date.issued2012-07-
dc.identifier.citationChemistry - A European Journal, v. 18, NO. 31, Page. 9485-9490en_US
dc.identifier.issn0947-6539;1521-3765en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201200069en_US
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/176151-
dc.description.abstractNon-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.description.sponsorshipThis work was supported by NIH grant P01 GM75913 (S. H. G.), NS28471 (B. K.), the European Community's Seventh Framework Programme FP7/2007-2013 under grant agreement number HEALTH-F4-2007-201924, EDICT Consortium (B. B., K. G., U. G.), the Danish National Research Council (C.J.L., U. G.), the Lundbeck Foundation (S. G. F. R., C.J.L., U. G.), the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (grant number 2008-0061856 to P. S. C., K. H. C.), and NIH grants R01 GM95538 and R21 HL087895 (to L. G.). R. R. was funded by the Defence, Science and Technology Laboratories (DSTL), Porton Down, UK. We thank Philip Laible (Argonne National Laboratory) and, Elodie Point and Jean-Luc Popot (Universite Paris-7) for supplying membrane preparations from R. capsulatus and purple membrane, respectively. We also thank Chiara Lee and David Drew (Imperial College London) and, Jonathan Ruprecht (Medical Research Council-Mitochondrial Biology Unit, Cambridge) and Gary Cecchini (University of California, San Francisco) for providing purified GlpG and SQR samples, respectively.en_US
dc.languageenen_US
dc.publisherJohn Wiley & Sons Ltd.en_US
dc.subjectamphiphilesen_US
dc.subjectmembrane proteinsen_US
dc.subjectmolecular designen_US
dc.subjectsolubilizationen_US
dc.subjectstabilizationen_US
dc.titleA New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteinsen_US
dc.typeArticleen_US
dc.relation.no31-
dc.relation.volume18-
dc.identifier.doi10.1002/chem.201200069en_US
dc.relation.page9485-9490-
dc.relation.journalChemistry - A European Journal-
dc.contributor.googleauthorChae, Pil Seok-
dc.contributor.googleauthorRasmussen, Soren G. F.-
dc.contributor.googleauthorRana, Rohini R.-
dc.contributor.googleauthorGotfryd, Kamil-
dc.contributor.googleauthorKruse, Andrew C.-
dc.contributor.googleauthorManglik, Aashish-
dc.contributor.googleauthorCho, Kyung Ho-
dc.contributor.googleauthorNurva, Shailika-
dc.contributor.googleauthorGether, Ulrik-
dc.contributor.googleauthorGuan, Lan-
dc.contributor.googleauthorLoland, Claus J.-
dc.contributor.googleauthorByrne, Bernadette-
dc.contributor.googleauthorKobilka, Brian K.-
dc.contributor.googleauthorGellman, Samuel H.-
dc.sector.campusE-
dc.sector.daehak공학대학-
dc.sector.department생명나노공학과-
dc.identifier.pidpchae-
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