Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채필석 | - |
dc.date.accessioned | 2022-10-31T00:54:59Z | - |
dc.date.available | 2022-10-31T00:54:59Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | Chemical Science, v. 7, NO. 3, Page. 1933-1939 | en_US |
dc.identifier.issn | 2041-6520;2041-6539 | en_US |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2016/SC/C5SC02900G | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/176127 | - |
dc.description.abstract | Membrane proteins are amphipathic bio-macromolecules incompatible with the polar environments of aqueous media. Conventional detergents encapsulate the hydrophobic surfaces of membrane proteins allowing them to exist in aqueous solution. Membrane proteins stabilized by detergent micelles are used for structural and functional analysis. Despite the availability of a large number of detergents, only a few agents are sufficiently effective at maintaining the integrity of membrane proteins to allow successful crystallization. In the present study, we describe a novel class of synthetic amphiphiles with a branched tail group and a triglucoside head group. These head and tail groups were connected via an amide or ether linkage by using a tris(hydroxylmethyl) aminomethane (TRIS) or neopentyl glycol (NPG) linker to produce TRIS-derived triglucosides (TDTs) and NPG-derived triglucosides (NDTs), respectively. Members of this class conferred enhanced stability on target membrane proteins compared to conventional detergents. Because of straightforward synthesis of the novel agents and their favourable effects on a range of membrane proteins, these agents should be of wide applicability to membrane protein science. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grant number 2008-0061891 and 2013R1A2A2A03067623 to P. S. C. and A. S.). The work was also supported by Biotechnology and Biological Sciences Research Council (grant BB/K017292/1 to B. B.), by the National Science Foundation (grant MCB-1158085 to L. G.) and by the National Institutes of Health (grant R01 GM095538 to L. G.), by the Danish Council for Independent Research Sapere Aude program 0602-02100B (to C. J. L.) and the Lundbeck Foundation R108-A10755 (to C. J. L.). | en_US |
dc.language | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.title | A class of rigid linker-bearing glucosides for membrane protein structural study | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 7 | - |
dc.identifier.doi | 10.1039/c5sc02900g | en_US |
dc.relation.page | 1933-1939 | - |
dc.relation.journal | Chemical Science | - |
dc.contributor.googleauthor | Sadaf, Aiman | - |
dc.contributor.googleauthor | Mortensen, Jonas S. | - |
dc.contributor.googleauthor | Capaldi, Stefano | - |
dc.contributor.googleauthor | Tikhonova, Elena | - |
dc.contributor.googleauthor | Hariharan, Parameswaran | - |
dc.contributor.googleauthor | Ribeiro, Orquidea | - |
dc.contributor.googleauthor | Loland, Claus J. | - |
dc.contributor.googleauthor | Guan, Lan | - |
dc.contributor.googleauthor | Byrne, Bernadette | - |
dc.contributor.googleauthor | Chae, Pil Seok | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 생명나노공학과 | - |
dc.identifier.pid | pchae | - |
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