Effect of Osteoporotic Condition on Ventriculomegaly and Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage
- Title
- Effect of Osteoporotic Condition on Ventriculomegaly and Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage
- Author
- 한명훈
- Keywords
- bone density; hospitals; hydrocephalus; skull; subarachnoid hemorrhage
- Issue Date
- 2021-02
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- STROKE, Page. v. 52, no. 3, page. 994-1003
- Abstract
- BACKGROUND AND PURPOSE: Hydrocephalus is a common complication in aneurysmal rupture subarachnoid hemorrhage (SAH).
As both the bone and arachnoid trabeculae are composed of type 1 collagen, we identified the possible relationship between
bone mineral density and ventriculomegaly and shunt-dependent hydrocephalus (SDHC) development after aneurysmal
rupture SAH in younger patients.
METHODS: We measured frontal skull Hounsfield unit (HU) values on brain computed tomography upon admission, and mean
frontal skull HU values were used instead of T-score value. Hazard ratios were calculated using Cox regression analysis to
identify whether osteoporotic condition is an independent predictor for ventriculomegaly and SDHC after surgical clipping
for SAH in younger patients.
RESULTS: Altogether, 412 patients (≤65 years) who underwent surgical clipping for primary spontaneous SAH from a ruptured
aneurysm were enrolled in this 11-year analysis in 2 hospitals. We observed that the first tertile group of skull HU was an
independent predictor of SDHC after SAH compared with the third tertile of skull HU values (hazard ratio, 2.55 [95% CI,
1.25–5.20]; P=0.010). There were no significant interactions between age and skull HU with respect to ventriculomegaly
and SDHC in younger patients.
CONCLUSIONS: Our study suggests a relationship between possible osteoporotic conditions and ventriculomegaly and SDHC
development after SAH in younger patients. Our findings may be useful in predicting hydrocephalus in young SAH patients
using a convenient method of measuring skull HU value on brain computed tomography upon admission.
- URI
- https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031044https://repository.hanyang.ac.kr/handle/20.500.11754/175660
- ISSN
- 0039-2499; 1524-4628
- DOI
- 10.1161/STROKEAHA.120.031044
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- Effect of Osteoporotic Condition on Ventriculomegaly and Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage.pdfDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML