Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지영 | - |
dc.date.accessioned | 2022-10-19T07:19:41Z | - |
dc.date.available | 2022-10-19T07:19:41Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 62, NO 2, article no. 2, Page. 1-9 | en_US |
dc.identifier.issn | 0146-0404; 1552-5783 | en_US |
dc.identifier.uri | https://iovs.arvojournals.org/article.aspx?articleid=2772236 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/175572 | - |
dc.description.abstract | PURPOSE. To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). METHODS. In this prospective cohort study, probabilistic maps of the 26 white matter pathways associated with motor, cognitive, visual, and limbic/language functions were generated in 84 preterm infants using DTI obtained at term-equivalent age. The mean fractional anisotropy (FA) and mean diffusivity (MD) values were compared between those with and without ROP. Developmental outcomes were assessed using the third edition of Bayley Scales of Infant and Toddler Development (BSID-III) at 18 months of corrected age. Multiple regression analyses were performed to confirm the association among developmental outcomes, white matter pathways, and ROP or severe ROP after adjusting for potential confounders. RESULTS. The white matter pathways were insignificantly associated with ROP or severe ROP. There were no significant differences in the FA and MD values of the pathways between ROP infants treated with and without bevacizumab therapy. Furthermore, there were no significant differences in BSID-III scores between infants with and without ROP or severe ROP. The BSID-III scores at 18 months of age showed a significant association with FA or MD values in several pathways. CONCLUSIONS. ROP or severe ROP was insignificantly associated with maturation delay of the white matter pathways. Developmental outcomes were similar between preterm infants with and without ROP or severe ROP or between ROP infants with and without intravitreal bevacizumab therapy. | en_US |
dc.description.sponsorship | Supported by a National Research Foundation of Korea Grant funded by the Korean Government Ministry of Science and ICT (NRF-2021M3E5D1A01015175) and by the National Research Foundation of Korea Grant funded by the Korean Government MIST (NRF-2020-R1F1A1048529 and 2020-M3E5D9080787). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | en_US |
dc.subject | brain white matter; developmental outcome; retinopathy of prematurity | en_US |
dc.title | Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 62 | - |
dc.identifier.doi | 10.1167/iovs.62.2.2 | en_US |
dc.relation.page | 1-9 | - |
dc.relation.journal | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | - |
dc.contributor.googleauthor | Ahn, Seong Joon | - |
dc.contributor.googleauthor | Lee, Joo Young | - |
dc.contributor.googleauthor | Lee, Ji Young | - |
dc.contributor.googleauthor | Lee, Young-Jun | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Lee, Byung Ro | - |
dc.contributor.googleauthor | Kim, Jinsup | - |
dc.contributor.googleauthor | Lee, Hyun Ju | - |
dc.relation.code | 2021001904 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | mdjylee | - |
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