Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김진기 | - |
dc.contributor.author | 임창완 | - |
dc.date.accessioned | 2022-09-27T16:11:22Z | - |
dc.date.available | 2022-09-27T16:11:22Z | - |
dc.date.issued | 2022. 8 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000627373 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/174545 | - |
dc.description.abstract | The purpose of this study was to investigate high drug loading and enhanced skin permeation of solubilization of aceclofenac in Deep Eutectic Solvent loaded ultradeformable liposomes (ACF-DES-UDLs). Deep eutectic solvents (DESs) are solvents that attract attention for their melting and stabilizing properties as well as low toxicity and biodegradability. We designed a new DES with a molar ratio of 1:4 based on betaine, propylene glycol, and ethylene glycol. DES identified physical properties and increased solubility by a fold of 16,370 (from 20 μg/mL to 327.4 mg/mL) compared to the solubility in ACF water. ACF was solubilized using DES and then loaded into UDL. ACF-DES-UDLs were prepared by lipid film hydration and extrusion method with egg phosphatidylcholine as a bilayer and TW80 as an edge activator. The physical chemical properties of ACF-DES-UDLs were described in treatments of particle size, zeta potential, polydispersity index and entrapment efficiency. The deformability of ACF-DES-UDLs was compared with that of ACF-DES-loaded conventional liposomes (ACF-DES-CLs) using a steel pressure filter device. aceclofenac release from ACF-DES-UDLs was assessed by Dialysis membrane methods. In vitro skin permeation of aceclofenac was evaluated using Franz diffusion cell and skin permeation parameters were compared between ACF-Sol and ACF-DES-UDLs. ACF-DES-UDLs were successfully prepared with a particle size near 100 nm and showed a uniform particle size distribution. The entrapment efficiency of ACF-DES(BP)-UDLs and ACF-DES(BE)-UDLs at 51.6 ± 2.3% and 49.6 ± 4.6 %, respectively. In vitro release and deformability of ACF-DES-UDL were not different from ACF-DES-CLs. The skin permeation parameters of ACF-DES(BP)-UDLs and ACF-DES(BP)-CLs were 2.4 times and 1.33 times higher than ACFsol, respectively. | - |
dc.publisher | 한양대학교 | - |
dc.title | Preparation and evaluation of aceclofenac-loaded nanoparticulate carriers using deep eutectic solubilization technology for efficient transdermal delivery | - |
dc.title.alternative | 아세클로페낙의 효율적인 경피수송을 위한 공융용매 가용화 기술 적용 나노입자성 수송체의 제조 및 평가 | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 임창완 | - |
dc.contributor.alternativeauthor | Chang-Wan Lim | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 약학과 | - |
dc.description.degree | Master | - |
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